151例糖耐量低减患者中医证候及聚类情况分析

目的:探讨糖耐量低减(IGT)人群中医证候及证型特点,为临床施治提供依据。方法:通过OGTT试验筛选IGT病例,记录包括腰臀比、体质量指数等一般项目;采用设计的中医证候问卷,专人采集四诊资料,累计积分,聚类分析,归纳证型。结果:151例IGT患者在纳入调查的症状中,出现频数居前10位的依次是:健忘(62.3%)、夜尿频多(55.6%)、自汗(53.0%)、神疲乏力(51.0%)、脘腹胀满(49.7%)、口干咽燥(45.7%)、痰多(42.4%)、口渴喜饮(41.1%)、眼睛干涩(37.7%)、大便干结(35.8%)。聚类分析结果151例IGT患者患者中,气阴两虚型78例(51.7%),脾虚痰湿型52例(34.4%),阳虚血瘀型21例(13.9%)。结论:IGT的发病多与脾虚、气虚、阴虚、血瘀等因素有关;IGT患者中,气阴两虚证多见。

TCM syndrome and clustering analysis research of 151 cases of IGT patients

Objective: To study characteristics of TCM syndrome and syndrome type in impaired glucose tolerance(IGT) population to provide basis for clinical treatment application.Methods: selected IGT cases by OGTT test,recorded the general items including waist-hip ratio,body mass index;a TCM questionnaire was adopted,collected information on four diagnostic,accumulated the points,conducted a cluster analysis to summarize syndrome.Results: among the 151 cases of IGT patients involved in the symptom survey,the top 10 occurrence frequency sequence were as follows: forgetfulness(62.3%),nocturia(55.6%),spontaneous perspiration(53.0%),spiritlessness and fatigue(51.0%),abdominal distention(49.7%),dry mouth and throat(45.7%),excessive phlegm(42.4%),thirst with liking for fluids(41.1%),dry eyes(37.7%),dry bound stool(35.8%).Cluster analysis shows that among the 151 cases of patients with IGT,78 cases(51.7%) are type of deficiency of both Qi and Yin,52 cases(34.4%) are type of spleen-asthenia and phlegm-damp,21 cases(13.9%) are type of Yang deficiency and blood stasis.Conclusion: IGT incidence is relevant with some factors such as spleen asthenia,Qi deficiency,Yin deficiency,and blood stasis;deficiency of both Qi and Yin are very common in IGT patients.