Clinical and dosimetric predictors of late rectal toxicity after conformal radiation for localized prostate cancer: Results of a large multicenter observational study |
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Authors: | Gianni Fellin Tiziana Rancati Micaela Baccolini Emanuela Cagna Floranna Mauro Angelo Filippo Monti Riccardo Valdagni |
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Affiliation: | a Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento, Italy b Medical Physics, Ospedale San Raffaele, Milano, Italy c Prostate program, Scientific Directorate, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy d Radiotherapy and Medical Physics, Ospedale di Circolo, Varese, Italy e Department of Radiotherapy and Medical Physics, Ospedale “S. Anna”, Como, Italy f Department of Radiotherapy and Medical Physics, Institute for Cancer Research and Treatment, Candiolo, Italy g Department of Radiotherapy and Medical Physics, Ospedale Villa Maria Cecilia, Lugo, Italy |
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Abstract: | PurposeAssessing the predictors of late rectal toxicity after high-dose conformal radiotherapy for prostate cancer.MethodsOne thousand one hundred thirty-two patients entered a prospective observational multicentric study; late rectal toxicity was evaluated by a self-reported questionnaire. Results concerning bleeding and faecal incontinence of 718/1132 patients with a complete follow-up at 36 months were analysed. The correlation between a number of clinical-dosimetric parameters and moderate/severe toxicity was investigated by univariate and multivariate logistic analyses.ResultsFifty-two (7.2%) and 57/718 (7.9%) patients were scored as moderate/severe bleeders and faecal incontinents, respectively; 19/57 incontinent patients showed persistent incontinence at 36 months. Bleeding was mainly correlated with V75 Gy while severe bleeding was mainly correlated with the previous abdominal/pelvic surgery; a different rectal dose-volume relationship in the two groups of patients (with/without surgery) was found. Moderate/severe acute toxicity was weakly correlated to late bleeding. The best predictor of faecal incontinence was acute toxicity (OR = 4 and 7 for chronic and actuarial incontinence, respectively).ConclusionThe application of rectal dose-volume constraints limited the incidence of rectal bleeding. The risk of bleeding may be further reduced by limiting V75 Gy < 5% and, in the case of patients previously submitted to abdominal/pelvic surgery, V70 Gy < 15-20%. Faecal incontinence seems to be mainly a consequential effect after acute toxicity. |
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Keywords: | Prostate Radiotherapy Rectal toxicity Dose-volume effects |
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