Interplay of pharmacogenetic variations in ABCB1 transporters and cytochrome P450 enzymes |
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Authors: | Hee-Doo Yoo Yong-Bok Lee |
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Institution: | College of Pharmacy and Institute of Bioequivalence and Bridging Study, Chonnam National University, Gwangju 500-757, Korea. |
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Abstract: | Interindividual variability in oral drug efficacy and toxicity is commonly observed in all therapeutic areas. Importantly,
interindividual variability in drug uptake and metabolism can result in poor drug response, adverse drug reactions, or unfavorable
drug-drug interaction. One of the common causes of individual variations in drug response is genetic variation of drug transporters
and metabolizing enzymes. Pharmacogenetics are rapidly elucidating the inherited nature of these differences in drug disposition
and effects, thereby providing a stronger scientific basis for optimizing drug therapy on the basis of each patient’s genetic
constitution. Knowledge of the genotype-phenotype correlation and frequency distribution of functional single nucleotide polymorphisms
may be a valuable tool for individualizing drug therapy. This information can also be useful for explaining inter-individual
and inter-ethnic variations in drug response and/or adverse effects. In this review, we focus on the interplay between efflux
transporter (ATP-binding cassette, sub-family B (MDR/TAP), member 1/ABCB1) and cytochrome P450s according to genetic polymorphism. |
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