| NS-398对人食管癌细胞放射增敏机制的研究 |
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| 引用本文： | 龙辉,李欢,王洁莲,吴清明.NS-398对人食管癌细胞放射增敏机制的研究[J].胃肠病学和肝病学杂志,2011,20(12):1102-1104. |
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| 作者姓名： | 龙辉 李欢 王洁莲 吴清明 |
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| 作者单位： | 武汉科技大学附属天佑医院消化内科,湖北武汉,430064 |
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| 摘 要： | 目的探讨人食管癌放射抗拒细胞株侧群细胞（sP细胞）表达的变化。方法将人食管癌细胞株分为两组：对照组、实验组，对照组分别给予0、2、4、6、8Gy的X射线放射治疗诱导抗拒细胞株；实验组给予NS-398联合上述剂量的X线照射。流式细胞技术检测各组细胞中sP细胞的表达情况，统计分析sP细胞表达的差异。结果随着放射剂量的增加，SP细胞的表达增加，给予NS-398作用后，sP细胞的表达下降。结论sP细胞增加人食管癌细胞的放射抗拒性，抑制sP细胞的表达，能够降低人食管癌细胞的放射抗拒性。
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| 关 键 词： | 人食管癌细胞 侧群细胞 放射增敏 NS-398 |
Study of the radiation sensitive mechanism of NS-398 on human esophageal cancer cells |
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| LONG Hui
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LI Huan
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WANG Jielian
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WU Qingming.Study of the radiation sensitive mechanism of NS-398 on human esophageal cancer cells[J].Chinese Journal of Gastroenterology and Hepatology,2011,20(12):1102-1104. |
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| Authors: | LONG Hui LI Huan WANG Jielian WU Qingming |
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| Institution: | LONG Hui,LI Huan,WANG Jielian,WU QingmingDepartment of Gastroenterology,the Affiliated Tianyou Hospital of Wuhan University of Science and Technology,Wuhan 430064,China |
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| Abstract: | Objective To research the change of side population cells(SP cells) in human esophageal cancer radiation resistant cell lines.Methods The human esophageal cancer cell lines were divided into two groups: experiment group and control group.The control group was given 0,2,4,6,8 Gy of X-ray radiation therapy in order to induced resistance on cell lines;experiment group was given NS-398 combined with X-ray radiation dose above.The expression of SP cells was detected by flow cytometer,then the difference was anal... |
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| Keywords: | Human esophageal cancer cells Side population cell Radiation sensitization NS-398 |
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