| 潍坊市中小学生重组酵母乙型肝炎疫苗接种效果 |
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| 引用本文： | 徐斌,霍锡元.潍坊市中小学生重组酵母乙型肝炎疫苗接种效果[J].医学动物防制,2008,24(10). |
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| 作者姓名： | 徐斌 霍锡元 |
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| 作者单位： | 山东省,潍坊市疾病预防控制中心,261041 |
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| 摘 要： | 目的评价重组酵母乙型肝炎疫苗(以下称乙肝疫苗)在潍坊市中小学生中大规模接种后的效果。方法采用随机整群抽样法,选择奎文区中小学各1所。小学1-6年级和中学初一到高三的6-18岁1829名学生,接种重组酵母乙肝疫苗。1年后,采用ELISA检测血清中HBsAg、抗-HBc、抗-HBs。结果乙肝疫苗接种前后乙肝病毒标志物(HBVM)阳性率差异有统计学意义(x2=236.66,P<0.01);HBVM中,接种后抗-HBs阳性率显著高于接种前(x2=205.42,P<0.01);接种前后HBsAg总感染率、抗-HBc总感染率差异无统计学意义。结论中小学生大规模接种的效果较好,低年龄组人群应为乙肝疫苗大规模接种的优选对象。
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| 关 键 词： | 重组酵母 乙型肝炎疫苗 接种效果 随访研究 |
Subject effect of gene recombining Hepatitis B vaccination |
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| XU Bin,HUO Xi-yuan.Subject effect of gene recombining Hepatitis B vaccination[J].Chinese Journal of Pest Control,2008,24(10). |
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| Authors: | XU Bin HUO Xi-yuan |
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| Abstract: | Objective Evaluation of recombinant yeast hepatitis B vaccine (the hepatitis B vaccine) in Weifang City in primary and secondary school students in the effects of large-scale vaccination.Methods Stratified multi-stage clus-ter sampling was used to select 1 829 students between 6 and 1 8 years old from a middle school and a primary school of KuiWen District;ELISA was applied to determine serllm HBsAg-anti-HBc and anti-HBs of the students 1 year after vaccination with gene recombining hepatitis B vaccine.Results There wa$notable statistical significance between pre-immunization and after-immuniza-tion in the positive rate of HBVM (P
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| Keywords: | Gene recombining Hepatitis B vaccine Efleet of vaccination:Follow-up study |
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