病例对照家系设计中样本含量的估算

目的：探讨病例对照家系设计中样本含量的估算方法及影响因素。方法：在评价病例亲属和对照亲属再发风险的前提下，考虑亲属疾病表型的家庭相关，估计样本含量。结果：用实例说明了病例对照家系设计中样本含量估计方法的应用与影响因素和样本含量的关系。结论：家庭相关越大，需要的家庭数越多；家庭中亲属成员个数越多，需要的家庭数越少。

Sample Size Estimation for Case-control Family Design

Objective Discussing sample size estimation method and effect factors for case control family design. Methods The method for estimating sample size was given after allowing for reoccurring risk of relatives of cases and controls and familial correlation of disease phenotype among relatives.Results Actual use of the method for estimating sample size and the relationship between effect factors and sample size were illustrated by a example of case control family study of liver cancer.Conclusion The larger familial correlation is,the more the number of families required is. The more the number of relatives per family is,the smaller the number of families required is.