强直性脊柱炎病因学的研究进展

强直性脊柱炎(AS)发病机制至今尚不明确,被认为是一类与遗传、环境等多因素相关的慢性炎症性疾病。遗传方面,人类白细胞抗原B27是最早被提出的与该病发病有关的基因,近年来大量研究发现其他主要组织相容性复合体(MHC)类基因以及一些非MHC基因也可能参与了AS的发病。环境方面则主要是认为某些微生物感染可能参与了AS的发病。随着感染与免疫系统疾病,尤其是脊柱关节病之间关联的发现,感染在AS发病中作为环境因素的地位也逐渐被认识和重视。

Research Progress in Etiology of Ankylosing Spondylitis

Ankylosing spondylitis(AS) is a chronic inflammatory disease.Its pathogenesis remains unclear,which may involve many factors,such as genetic factors,environmental factors,and so on.In the aspect of genetic factors,after the initial discovery of HLA-B27,other major histocompatiblity complex(MHC) genes and non-MHC gene associated with AS were reported gradually.For environmental factors,it is thought that certain microorganisms may participate in the pathogenesis of AS.With the further understanding of the association between infection and immune diseases,especially infection and spondyloarthropathy,the role of infection in AS has gained more and more attention.