支气管哮喘患儿治疗前后血清GM-CSF、IL-8和IL-6联检的临床意义

目的：探讨了支气管哮喘患儿血清GM—CSF、IL-8和IL-6水平的变化及意义。方法：应用放射免疫分析对32例支气管哮喘患儿进行了血清GM—CSF、IL-8和IL-6水平测定，并与30例正常健康儿作比较。结果：支气管哮喘患儿血清GM—CSF、IL-8和IL-6水平非常显著地高于正常儿组（P〈0．01）。经治疗3个月后则与正常儿比较无显著性差异（P〉0．05）。结论：血清GM—CSF、IL-8和IL-6水平的异常升高足支气管哮喘患儿发病的病理因素之一．有重要的临床价值。

Clinical Significance of Determination of Changes of Serum GM-CSF, IL-8, IL-6 Levels After Treatment in Pediatric Patients with Bronchial Asthma

Objective To investigate the changes of serum GM-CSF,IL-8 and IL-6 levels both before and after treatment in pediatric patients with bronchial asthma.Methods Serum GM-CSF,IL-8 and IL-6 levels were measured with RIA in 32 pediatric patients with bronchial asthma both before and after treatment as well as in 30 controls.Results Before treatment,the serum GM-CSF,IL-8,IL-6 levels were significantly higher in the patients than those in the controls(P<0.01).After 3 months treatment,the levels were not significantly different from those in controls(P>0.05).Conclusion Abnormal high serum GM-CSF,IL-8,IL-6 levels played important role in the pathogenesis of bronchial asthma in children.