经会阴地^125I粒子组织间植入治疗局限性前列腺癌临床研究（附10例报告）

目的探讨经直肠超声（TRUS）引导下经会阴^125I粒子永久性组织间植入治疗局限性前列腺癌（PCa）的临床疗效。方法对10例临床局限性前列腺癌患者采用TRUS下经会阴^125I粒子永久性组织间植入的治疗情况进行回顾性研究。结果10例患者手术均成功，并发症少，术后3月内PSA均下降到正常值以下，随访9—38个月，PSA≤0．2ng／mL，均无生化失败，均存活。结论^125I粒子永久性组织间植入治疗局限性前列腺癌的临床疗效好，生化失败少，远期并发症少，生活质量高，是治疗局限性前列腺癌的良好方案。

Clinical analysis of permanent transperineal 125I seeds implantation for localized prostate cancer under transrectal ultrasound guidance (report of 10 cases)

Objective To discuss the clinical curative effect of permanent transperineal ^125I seeds implantation for localized prostate cancer. Methods ^125I seeds were implanted transperineal permanently under transrectal ultrasound （TRUS） guidance in 10 patients with localized prostate cancer. Then the effect was analysed retrospectively. Results The surgery was successfully performed in all 10 cases with few complications. PSA fell to 4 ng/mL within 3 months, and 9 to 38 months of follow-up found no PSA progression （PSA≤0. 2 ng/mL in all cases）. Conclusion Permanent transperineal ^125I seeds implantation in localized prostate cancer achieves a good clinical effect, with less failure of PSA and few complications. It can be a favorable choice for localized prostate cancer.