急性鼠药中毒的苯巴比妥疗法

目的:对88例急性鼠药(氟乙酰胺、毒鼠强)中毒导致中枢神经系统功能受损病人进行苯巴比妥疗法,寻找更好的防治措施。方法:两组病人入院后均常规洗胃,使用特效解毒药(乙酰胺、二巯基丙磺酸钠),及时用地西泮、苯巴比妥控制抽搐,昏迷病人佐以脑细胞营养药胞二磷胆碱、纳洛酮治疗。结果:本组88例病人有48例患儿出现抽搐,40例合并多脏器功能衰竭,经综合性治疗82例(93%)治愈,死亡6例(7%)。死亡与毒量大、发病时间长及多脏器功能衰竭等原因有关(P<0.01)。结论:急性鼠药中毒致中枢神经系统功能受损多脏器功能衰竭发生率高在综合治疗基础上佐以苯巴比妥是临床上有效的治疗方法

Phenobarbital treatment to acute intoxication of mice killer

Objective: In order to find better preventions and treatments, phenobarbital was used to treat 88 patients with functional lesion of central nervous system caused by acute intoxication of fluoroacetamide or tetramine. Methods: Two groups of patients got routine gastric lavage and specific toxicides (acefamide, Na-DMPS) and phenobarbital were used to control tic in time after admission. Brain cell nutricentical citicoline and naloxonewere used to treat coma patients. Results: All of the 88 patients had functional lesion in nervous system and other organs. 48 patients had tic and complicated multiple organ failure. 83 patients were cured by combinational treatment (cure rate was 94%) and 5 died (6%). Their death was related to a great quantity of poison and a relative long time before the treatment (P < 0.01). Conclusion: Acute intoxication of fluoroacefamide on fetramine induced high incidence rate of nervous system functionallesion and MOF. It is an effective treatment to take active complicated treatment with phenobarbital.