| 人微小病毒B19与乙肝病毒相关肝病的临床关系 |
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| 引用本文： | 唐星火,吴长亮.人微小病毒B19与乙肝病毒相关肝病的临床关系[J].胃肠病学和肝病学杂志,2010,19(2). |
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| 作者姓名： | 唐星火 吴长亮 |
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| 作者单位： | 广西医科大学第一附属医院(西院)消化科,广西,南宁,530007 |
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| 摘 要： | 目的 探讨人微小病毒B19在乙肝病毒相关肝病患者中的感染情况及其对这些疾病的影响.方法 应用ELISA技术检测原发性肝癌、肝硬化、慢性乙型肝炎三组患者(各50例)和健康对照组(50例)血清中HPV B19特异性抗体IgM(B19-IgM),同时检测其丙氨酸氨基转移酶、天冬氨酸氨基转移酶、肝功能Child-Pugh评分,分析HPV B19感染对肝脏功能的影响.结果 乙肝病毒相关肝病组人微小病毒B19感染率(16.7%)远高于正常对照组(2%),差别有显著性(P<0.05);原发性肝癌人微小病毒B19-IgM阳性率(28%)远高于慢性乙型肝炎组(10%)、肝硬化组(12%)及正常对照组(2%)(P<0.05);肝硬化组人微小病毒B19-IgM抗体阳性率明显高于正常对照组(P<0.05);原发性肝癌组中人微小病毒B19-IgM阳性患者转氨酶(ALT、AST)水平、肝功能Child-Pugh评分及肝癌分期较阴性者高,差异有统计学意义(P<0.05).结论 乙肝病毒相关肝病患者合并人微小病毒B19的感染常见,其中原发性肝癌组感染率最高;且转氨酶的水平及肝功能Child-Pugh评分高于未感染者,提示受人微小病毒B19感染的原发性肝癌患者肝功能受损将更严重.
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| 关 键 词： | 人微小病毒B19 原发性肝癌 肝硬化 慢性乙型肝炎 |
The clinical relationship between human parvovirus B19 infection and hepatitis B-related liver diseases |
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| TANG Xinghuo,WU Changliang.The clinical relationship between human parvovirus B19 infection and hepatitis B-related liver diseases[J].Chinese Journal of Gastroenterology and Hepatology,2010,19(2). |
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| Authors: | TANG Xinghuo WU Changliang |
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| Institution: | TANG Xinghuo,WU Changliang Department of Gastroenterology,the First Affiliated Hospital of Guangxi Medical University (the Western Unit),Nanning 530007,China |
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| Abstract: | Objective To study the effect of human parvovirus B19 (HPV B19) infection in patients with hepatitis B-related liver diseases.Methods Positive rates of serum B19-IgM in 3 groups patients-HCC,LC,CHB were examined by ELISA.Each group contained 50 patients compared to 50 cases of healthy control group.The aminotransferase (ALT,AST) and Child-Pugh score to all subjects were examined.The effect of liver function in patients with hepatitis B-related liver disease whom also infected with HPV B19 was analyzed.Resul... |
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| Keywords: | Human parvovirus B19 Hepatocellular carcinoma Liver cirrhosis Chronic hepatitis B |
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