An improved synthesis of carbon-11 labeled acetoacetic acid and an evaluation of its potential for the investigation of cerebral pathology by positron emission tomography |
| |
| Affiliation: | 1. Department of Neurosurgery, University Hospital Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands;2. Department of Nuclear Medicine, University Hospital Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands;1. Shandong Institute for Food and Drug Control, Jinan, Shandong 250101, PR China;2. Cancer Center, Linyi''s People Hospital, Linyi, Shandong 276000, PR China;3. Lab of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China;1. Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, No. 270 DongAn Road, Shanghai 200032, PR China;2. Department of Oncology, Shanghai Medical College, Fudan University, No. 270 DongAn Road, Shanghai 200032, PR China;3. Pancreatic Cancer Institute, Fudan University, No. 270 DongAn Road, Shanghai 200032, PR China;4. Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou, PR China;1. Key Laboratory of Surface and Interface Chemistry of Jilin Province, College of Chemistry, Jilin University, Changchun 130012, Jilin, China;2. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, Jilin, China;1. Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, South Africa;2. Department of Surgery, Faculty of Health Sciences, University of Pretoria, South Africa |
| |
| Abstract: | 1-11C-acetoacetic acid was synthesized by carboxylation of the acetone carbanion. Purification was carried out using HPLC. The product was obtained with a radiochemical yield of up to 58%, corrected for decay, in a total preparation time of 30 min. The distribution of 1-11C-acetoacetic acid after injection into adult Wistar rats and cats was investigated by PET. When the tracer was injected into cats, 3 weeks after inflicting a unilateral freezing lesion upon the brain, accumulation of 1-11C-acetoacetic acid in the ipsilateral brain hemisphere was observed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
