Comparison of age-associated changes of c-myc gene methylation in liver between man and mouse |
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| Institution: | 1. Department of Radiation Research, Tohoku University School of Medicine, Sendai 980, Japan;2. Radiation Biology Center, Kyoto University, Kyoto 606, Japan;3. Department of Analytical Chemistry, Kyoto Pharmaceutical University, Kyoto 607, Japan;4. Department of Legal Medicine, Faculty of Medicine, Kyoto University, Kyoto 606, Japan;5. Research Reactor Institute, Kyoto University, Osaka 590-04, Japan;6. Department of Forensic Medicine, Tohoku University School of Medicine, Sendai 980, Japan;7. Department of Pathology, Faculty of Medicine, Osaka University, Osaka 530, Japan;1. Department of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany;2. Institute for Physiology and Pathophysiology, University of Heidelberg, INF 326, D-69120, Heidelberg, Germany;3. DZHK (German Centre for Cardiovascular Research), Partner site Heidelberg/Mannheim, INF 410, D-69120, Heidelberg, Germany;4. Department of Molecular Neurobiology, Max-Planck-Institute for Medical Research, Jahnstraße 29, D-69120, Heidelberg, Germany;1. Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel;2. Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;1. Key Laboratory of Brain Functional Genomics, MOE and STCSM, Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China;2. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, China |
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| Abstract: | Age-associated changes in DNA methylation of the c-myc gene in lever were compared between humans and mice which have large differences in aging rate. Although the overall methylation profiles of the gene and their age-related changes were found to be similar, the rate of change was much slower in humans than in mice. It suggests that the age-associated alteration of c-myc gene methylation is closely related to biological aging rather than to chronological aging. |
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