Utility of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients with Fever of Unknown Origin Diagnosed as Lymphoma |
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| Authors: | Zi-Ke Sheng Jin Ye Jun-Jie Li Kui Zhao Ji-Fang Sheng |
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| Institution: | aInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, PR China;bDepartment of Infectious DIseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou, PR China;cPET Center, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China |
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| Abstract: | ObjectiveTo assess the efficacy of fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET)/computed tomography (CT) in the diagnosis of patients with fever of unknown origin (FUO), who were finally diagnosed as lymphoma.Subjects and MethodsA retrospective study was performed in the First Affiliated Hospital, School of Medicine of Zhejiang University, China, from March 2009 to March 2012. The PET/CT images of consecutive patients with FUO were analyzed. Within 1 week of PET/CT scanning, additional histological tests were also performed if clinically needed.ResultsA total of 73 consecutive patients were included. Of these, 34 (47s%) had a PET/CT finding suggestive of the presence of lymphoma and 29 (85s%) had a diagnosis of confirmed lymphoma; 39 (53s%) had a PET/CT result revealing the absence of lymphoma and 4 (10s%) were diagnosed by biopsy as having lymphoma. The most frequent lymphoma diagnosis was peripheral T cell lymphoma (n = 16; 55s%), followed by diffuse large B cell lymphoma (n = 9; 31s%). The accuracy of PET/CT was 88s%.ConclusionIn this study, PET/CT had high diagnostic accuracy in patients with FUO resulting from lymphoma, which indicated that PET/CT scanning was a valuable diagnostic tool for these groups of patients with FUO.Key Words: Fever of unknown origin, Positron emission tomography, Computed tomography, Diagnosis, Lymphoma |
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