| 阿克曼氏菌与动脉粥样硬化关系的研究进展 |
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| 引用本文： | 赵鹏,郑玉琪,田进伟,刘新新. 阿克曼氏菌与动脉粥样硬化关系的研究进展[J]. 中国动脉硬化杂志, 2023, 31(5): 456-460 |
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| 作者姓名： | 赵鹏 郑玉琪 田进伟 刘新新 |
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| 作者单位： | 哈尔滨医科大学附属第二医院心内科,黑龙江省哈尔滨市 150001;心肌缺血教育部重点实验室, 黑龙江省哈尔滨市 150001;南华大学附属第一医院心内科,湖南省衡阳市 421001 |
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| 基金项目： | 心肌缺血教育部重点实验室开放课题(KF202011) |
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| 摘 要： | 动脉粥样硬化(As)是一种复杂的慢性炎症性疾病,是导致缺血性心脏病和中风在内的心血管疾病(CVD)的主要病因,在世界范围内造成很高的发病率和死亡率。近年来,肠道菌群在As中的作用受到广泛关注。而阿克曼氏菌作为一种重要的抗As作用的有益菌却少有综述。深入探讨As发病机制及潜在治疗方法是当前医学发展的焦点。因此,文章就阿克曼氏菌如何发挥抗As作用及与抗As药物之间的关系予以综述。
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| 关 键 词： | 动脉粥样硬化 阿克曼氏菌 小檗碱 他汀 二甲双胍 |
| 收稿时间： | 2022-08-31 |
| 修稿时间： | 2022-10-29 |
Research progress in the relationship between Akkermansia and atherosclerosis |
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| ZHAO Peng,ZHENG Yuqi,TIAN Jinwei,LIU Xinxin. Research progress in the relationship between Akkermansia and atherosclerosis[J]. Chinese Journal of Arteriosclerosis, 2023, 31(5): 456-460 |
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| Authors: | ZHAO Peng ZHENG Yuqi TIAN Jinwei LIU Xinxin |
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| Affiliation: | Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China;The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang 150001, China;Department of Cardiology, the 1st Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China |
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| Abstract: | Atherosclerosis (As), a complex chronic inflammatory disease, that is a major cause of cardiovascular diseases (CVD) including ischemic heart disease and stroke, causing high morbidity and mortality worldwide. In recent years, the role of gut microbiota in atherosclerosis has received extensive attention. However, as an important anti-atherosclerosis beneficial bacteria, Akkermansia is rarely reviewed. In-depth study of the pathogenesis and potential treatment of atherosclerosis is the focus of current medical development. Therefore, this article reviews how Akkermansia exerts its anti-atherosclerotic effect and its relationship with anti-atherosclerotic drugs. |
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| Keywords: | atherosclerosis Akkermansia berberine statin metformin |
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