Predictors of locoregional control in stage I/II oral squamous cell carcinoma classified by AJCC 8th edition |
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| Affiliation: | 1. Department of Head and Neck Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, India;2. Institute of Experimental Endocrinology Oncology, Naples, Italy;3. Department of Pathology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, India;1. Republican Centre for Thyroid Tumours, Department of Pathology, Nezavisimosty Av., 64, 220013, Minsk, Belarus;2. Republican Centre for Thyroid Tumours, Head and Neck Surgery Department, Nezavisimosty Av., 64, 220013, Minsk, Belarus;3. United Institute of Informatics Problems, National Academy of Sciences of Belarus, Surganova St. 6, 220012, Minsk, Belarus;4. New York Ear, Nose and Throat Institute, 1810 Voorhies Ave, Brooklyn, NY, 11235, United States;5. Department of Surgery, University of Hong Kong, Hong Kong;6. School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia;1. Department of Surgery, Catharina Hospital Eindhoven, the Netherlands;2. GROW: School of Oncology and Developmental Biology, University of Maastricht, Maastricht, the Netherlands;1. Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China;2. The No. 313 Hospital of PLA, Huludao, China;1. Scandinavian Surgical Outcomes Research Group (SSORG), Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 416 85, Gothenburg, Sweden;2. Region Västra Götaland, Sahlgrenska University Hospital, Department of Pediatric Oncology, 416 85, Gothenburg, Sweden;3. Region Västra Götaland, Sahlgrenska University Hospital, Department of Surgery, 416 85, Gothenburg, Sweden;4. Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, 405 30, Gothenburg, Sweden;5. Center for Health and Performance, Institute of Food, Nutrition, and Sports Science, University of Gothenburg, 405 30, Gothenburg, Sweden;6. Region Västra Götaland, Sahlgrenska University Hospital, Department of Medicine, Geriatrics, and Emergency Medicine, 416 85, Gothenburg, Sweden;7. Health Metrics Unit, The Sahlgrenska Academy, University of Gothenburg, Sweden |
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| Abstract: | ObjectivesTo study the determinants of locoregional control (LRC) on stage I/II oral squamous cell carcinoma (OSCC) classified by AJCC 8th edition.MethodsRetrospective analysis from 296 patients of pT1-2N0 oral OSCC treated with surgery (wide local excision and selective neck dissection). Those receiving adjuvant therapy were excluded. Multivariate analysis was performed for impact of adverse pathological features (APFs) on LRC.ResultsIn stage I, LRC was impacted by perineural invasion (PNI) (HR 7.72, p = 0.010, 95% CI 1.64–36.26) and moderate/poor differentiation (MD/PD) (HR 3.04, p = 0.049, 95% CI 0.99–9.25). In stage II, LRC was impacted by depth of invasion (DOI) (HR 1.59, p = 0.014, 95% CI 1.099–2.32), PNI (HR = 2.86, p = 0.005, 95% CI 1.36–5.98). Combined MD/PD and PNI were associated with worse LRC than either feature individually (HR = 4.12, p < 0.001, 95% CI 2.16–7.85).ConclusionPNI and differentiation accurately predict LRC in AJCC 8th edition classified stage I/II OSCC. PNI was a stronger predictor of locoregional failure than DOI in stage II disease. By incorporating these parameters, we can improve precision in staging of early OSCC and identify potential candidates for treatment escalation to improve outcomes. |
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| Keywords: | Oral squamous cell carcinoma Adverse pathological feature Perineural invasion Differentiation AJCC 8th edition |
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