Aging of the skin barrier |
| |
| Affiliation: | 1. CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan;2. Pembroke Pines, Florida, USA;1. Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane, Dessau, Germany;2. Private Practice, Pembroke Pines, Florida, USA;1. Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic;2. BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic;3. Department of Dermatovenereology, First Faculty of Medicine, Charles University, Prague, Czech Republic;4. Department of Plastic Surgery, Third Faculty of Medicine, Charles University, Prague, Czech Republic |
| |
| Abstract: | The skin barrier is mainly present in the stratum corneum (SC), composed of corneocytes surrounded by intercellular lipid lamellae, and attached by corneodesmosome. The tight junction attached to the lateral walls of keratinocytes in the upper part of the stratum granulosum is also included in the skin barrier. During aging, the following structures and functions of the skin barrier are changed or disturbed: (1) skin barrier structure, (2) permeability barrier function, (3) epidermal calcium gradient, (4) epidermal lipid synthesis and SC lipid processing, (5) cytokine production and response after insults, (6) SC acidity, (7) SC hydration, and (8) antimicrobial barrier. Patients with diabetes also show changes in the skin barrier similar to those in aged skin, and the characteristics of the skin barrier are very similar. Understanding the pathogenic mechanisms of the skin barrier in aging will permit us to develop therapeutic strategies for aged or diabetic skin. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
