Evaluation of the Th17 pathway in psoriasis and geographic tongue |
| |
| Affiliation: | 1. Department of Pathology, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brazil;2. Graduate Program in Pathology, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brazil;3. Sector of Dermatology, Medical Clinic Department, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil |
| |
| Abstract: | BackgroundPsoriasis is a skin-articular disease with unclear etiopathogenesis. It has been suggested that the disease is immune-mediated by T-lymphocytes, predominantly Th17 cells. Similar to psoriasis, geographic tongue is an inflammatory disease with participation of Th17 cells and direct correlation with psoriasis.ObjectiveTo investigate and compare the inflammatory responses and the Th17 pathway in psoriasis and geographic tongue.MethodsThis was a cross-sectional study with 46 participants that were categorized into three groups: (A) patients with psoriasis vulgaris; (B) patients with geographic tongue and psoriasis; (C) patients with geographic tongue without psoriasis. All patients underwent physical examination, and a skin and oral biopsy for histopathological examination and immunohistochemical analysis with anti-IL6, anti-IL17, and anti-IL23 antibodies.ResultsHistological analysis of all lesions showed mononuclear inflammatory infiltrate. However, moderate intensity was prevalent for the patients with geographic tongue and psoriasis and geographic tongue groups. Immunopositivity for the antibodies anti-IL6, anti-IL17, and anti-IL23 revealed cytoplasmic staining, mainly basal and parabasal, in both psoriasis and geographic tongue. Regarding IL-6, in patients with geographic tongue and psoriasis cases the staining was stronger than in patients with geographic tongue without psoriasis cases. IL-17 evidenced more pronounced and extensive staining when compared to the other analyzed interleukins. IL-23 presented similar immunopositivity for both geographic tongue and psoriasis, demonstrating that the neutrophils recruited into the epithelium were stained.Study limitationThis study was limited by the number of cases.ConclusionThe inflammatory process and immunostaining of IL-6, IL-17, and IL-23 were similar in geographic tongue and psoriasis, suggesting the existence of a type of geographic tongue that represents an oral manifestation of psoriasis. |
| |
| Keywords: | Glossitis, Benign migratory Psoriasis Th17 cells |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
