Shear Wave Elastography in Rectal Cancer Staging,Compared with Endorectal Ultrasonography and Magnetic Resonance Imaging |
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| Institution: | 2. Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom;3. Department of Cardiovascular Diseases, University of Leuven, University Hospital Gasthuisberg, Leuven, Belgium;2. Department of Stomatology, Peking University People''s Hospital, Beijing, China;3. Department of Ultrasound, Shuangyashan People''s Hospital, Shuangyashan, Heilongjiang, China;2. Ultrasound Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;3. Department of Emergency Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA;4. Department of Imaging Diagnostics, Policlinico Umberto I, University Sapienza, Rome, Italy;5. Berner Institut für Hausarztmedizin (BIHAM), Universität Bern, Bern, Switzerland;11. Ultrasound Section, Division of Surgery, Department of Gastroenterology, Herlev Hospital Copenhagen Academy for Medical Education and Simulation Ultrasound Section, University of Copenhagen, Copenhagen, Denmark;12. Diagnostic Radiology Institute, Paula Stradina Clinical University Hospital, And Radiology Research Laboratory, Riga Stradins University University of Latvia, Riga, Latvia;8. Department of Obstetrics and Gynecology And Sono Education Academy, University Hospital Bonn, Bonn, Germany;9. College of Nursing and Health Sciences, Flinders University, Adelaide, SA, Australia;2. Duke University, Durham, North Carolina, USA;3. Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark;4. Duke University Hospital, Durham, North Carolina, USA |
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| Abstract: | The goal of the study described here was to investigate the value of shear wave elastography (SWE) in pre-operative staging of rectal cancer. Fifty-five patients with rectal cancer underwent pre-operative conventional endorectal ultrasonography (ERUS), SWE and enhanced magnetic resonance imaging (MRI) examinations. Pathologic results were used as the gold standard for cancer staging. The concordance rate with pathologic stage by ERUS and MRI and the stiffness values measured by SWE for tumors in different stages were compared. The concordance rates for cancer staging were 72.7% and 70.9% for conventional ERUS and enhanced MRI, respectively; the difference was not significant (p > 0.05). SWE indicated that the mean and maximum stiffness values of the tumors increased with advance in stage. The differences in stiffness values between T1 and T2, T1 and T3–4, as well as T2 and T3–4, were all statistically significant (p < 0.001). When the maximum stiffness values of 65.0 and 90.7 kPa are used for the diagnosis of T1, T2 and local advanced rectal cancer, the concordance rate of cancer staging was 85.5%, which was slightly higher than those of ERUS and MRI, although the difference was not statistically significant (p > 0.05). SWE is useful in judging the depth of invasion of rectal tumors. The value of tumor stiffness can provide a quantifiable indicator for pre-operative diagnosis of cancer staging and can be used as a supplement to conventional ERUS. Further studies with larger sample sizes are needed. |
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