High cytoplasm HABP1 expression as a predictor of poor survival and late tumor stage in pancreatic ductal adenocarcinoma patients |
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| Affiliation: | 1. Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China;2. Department of Plastic & Reconstructive Surgery, Shanghai Ninth People''s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200011, China;1. Department of Surgery Oncology and Gastroenterology (DISCOG), University of Padua, Italy;2. Surgical Oncology, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy;3. Department of Surgical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia;4. Cork Cancer Research Centre, Cork, Ireland;5. Oncologic Gynecology Unit, Sant''Orsola-Malpighi Hospital, Bologna, Italy;6. 3rd Orthopaedic and Traumatologic Clinic Prevalently Oncologic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy;7. Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia;8. Christie NHS Foundation Trust, CRUK Manchester Institute, The University of Manchester, Manchester, M20 4GJ, UK;9. University of Ljubljana, Faculty of Electrical Engineering, Ljubljana, Slovenia;10. Department of Industrial Engineering, University of Padua, Italy;1. Department of Orthopaedics and Trauma, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, Austria;2. Comprehensive Cancer Centre Graz, Graz, Austria;3. Department of Orthopaedic Surgery, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands;4. Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria;5. Department of Experimental Therapeutics, The UT MD Anderson Cancer Center, Sout Campus Research Building 4, 1901 East Road, Houston, TX, USA;6. Division of Thoracic and Hyperbaric Surgery, Medical University of Graz, Auenbruggerplatz 29, 8036, Austria;7. Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria;8. Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands;9. Mathematical Institute Leiden University, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands;1. Department of Visceral, Transplantation and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria;2. Department of Surgery, Paracelsus Medical University, Salzburg, Austria;3. Institute of Pathology, Paracelsus Medical University, Salzburg, Austria;4. Department of Surgery, Medical University Graz, Graz, Austria;5. Department of Surgery, Elisabethinen Hospital, Linz, Austria;6. Department of Surgery, Kaiser Franz Josef Hospital, Vienna, Austria;7. Department of Surgery, Hospital Sisters of Mercy Linz, Linz, Austria;8. Department of Surgery, General Hospital Horn, Horn, Austria;9. Department of Internal Medicine I, Paracelsus Medical University, Salzburg, Austria;10. Department of Surgery, General Hospital Dornbirn, Dornbirn, Austria;1. Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;3. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China |
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| Abstract: | BackgroundHyaluronan-binding protein 1 (HABP1) overexpression has been confirmed in different malignancies and found to be strongly associated with tumor development and progression. The aim of the present study was to explore the impact of HABP1 in pancreatic ductal adenocarcinoma (PDAC) patients.MethodHABP1 expression was evaluated in 89 PDAC specimens.ResultsThe expression of HABP1 was significantly higher in tumor tissues than that in adjacent normal tissues. High nucleus HABP1 expression and high cytoplasm HABP1 expression were both detected in PDAC tissues. Overall survival analysis by optical density showed that the mean survival was similar between patients with low and high optical density values of HABP1 expression (P = 0.312). The similar result was also found between patients with low-moderate or high nucleus HABP1 expression (P = 0.275). However, the mean survival was significantly poorer in patients with cytoplasm HABP1 overexpression (P < 0.001). High cytoplasm HABP1 expression was strongly correlated with late tumor stages, arterial involvement, lymph node metastasis and carbohydrate antigen 19-9 levels.ConclusionHigh cytoplasm HABP1 expression may prove to be a predictor of poor survival and late tumor stage in PDAC patients. HABP1 could serve as a promising biomarker to identify subsets of PDAC patients with high malignant clinical behavior. |
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| Keywords: | Pancreatic ductal adenocarcinoma Hyaluronan binding protein 1 Survival Tumor stage Biomarker |
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