Analysis of clinicopathological features and prognosis of 1315 cases in colorectal cancer located at different anatomical subsites |
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| Institution: | 1. Department of Gastrointestinal Surgery, Second Affiliated Hospital of Dalian Medical University, NO. 467, Zhongshan Road, Dalian, 116023, China;2. Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, NO. 9, Lvshun South Road, Dalian, 116044, China;1. Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China;2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China;3. West China School of Medicine, Sichuan University, Chengdu, Sichuan, China;1. Federal University of Triângulo Mineiro, Praça Manoel Terra, 330, 38015-050, Uberaba, MG, Brazil;2. Federal University of Uberlândia, Av. João Naves de Ávila, 120, Santa Mônica, Uberlândia, MG, 38408-100, Brazil;1. National Atomic Energy Commission, (CNEA), Constituyentes Atomic Center, Research, Applications Management, Av. General, B1650KNA, San Martín, Buenos Aires, Argentina;2. National Scientific and Technical Research Council (CONICET), C1425FQB, CABA, Argentina;3. Italian Hospital of Buenos Aires (HIBA), Department of Dermatology, Experimental Dermatology, C1199ABB, CABA, Argentina;4. Italian Hospital of Buenos Aires (HIBA), Department of Anatomic Pathology, C1199ABB, CABA, Argentina;5. Laboratory of Bioinformatics, Curitiba (PR), Federal University of Paraná (UFPR), Professional and Technological Education Sector, Polytechnic Center Laboratory of Bioinformatics and Systems Biology, PPG-Bioinformática Jardim das Américas, 81531-970, Curitiba, PR, Brazil;6. Federal University of Rio Grande do Sul (UFRGS), Institute of Basic Health Sciences (ICBS), Department of Biochemistry, Laboratory of Cellular Biochemistry, 90035-003, Porto Alegre, RS, Brazil;7. National Institutes of Science & Technology, Translational Medicine (INCT-TM), 90035-903, Porto Alegre, RS, Brazil;8. National University of San Martin, Miguelete Campus, School of Science and Technology, B1650KNA, Villa Lynch, Buenos Aires, Argentina;1. Department of Clinical Medicine, Jiangsu Vocational College of Medicine, Yancheng, China;2. Department of Oncology Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;3. Jiangsu Cancer Hospital, Medical School of Nanjing University, Nanjing, China;4. Institute of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou, China;5. Department of Oncology surgery, Taikang Xianlin Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China;6. Department of Hand Surgery, Plastic Surgery and Aesthetic Surgery, Ludwig-Maximilians University, Munich, Germany |
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| Abstract: | PurposeCompare and analyze the clinicopathological features and prognosis of 1315 patients with colorectal cancer located at different anatomical subsites.MethodsA retrospective study was conducted to analyze the clinicopathological features and prognosis from 1315 patients with colorectal cancer who underwent surgery in the department of gastrointestinal surgery at the Second Affiliated Hospital of Dalian Medical University from January 2013 to January 2019. Among them, 287 patients were divided into the right-sided colon cancer (RCC) group; 329 patients were included into the left-sided colon cancer (LCC) group and the remaining 699 patients were assigned to the rectal cancer (RC) group. Clinicopathological features such as gender, age, pathological differentiation, neurovascular invasion, TNM stage, related tumor markers, maximum tumor diameter (MTD), median survival time and overall survival rate were extracted and analyzed.ResultsPatients in the RCC group had the oldest age of onset, highest positive rate of serum CA199 and greatest number of poorly differentiated adenocarcinomas among the three groups and significant statistical differences were found. The RC group had the highest positive rate of vascular invasion (42.9%) and the greatest number of patients in stage I and IV (19% and 3.9%, respectively). Besides, the number of patients with stage T1-T2 adenocarcinoma in RC group was also the highest among the three groups. There were no significant differences in gender, perineural invasion as well as serum levels of CEA, CA724 and CA242. The median survival time of RCC, LCC and RC were 72, 70 and 73 months, respectively, with significant inter-group differences (P = 0.049).ConclusionThe age of onset of right-sided colon cancer is the oldest on average and poorly differentiated tumors accounted for the highest proportion. Besides, average maximum tumor diameter is the largest in right-sided colon cancer. In terms of median survival time, LCC is worse than RCC and RC. Colorectal cancer at different anatomical subsites has different epidemiological, clinicopathological features and prognosis. Fully understanding the clinicopathological features of colorectal cancer at different anatomical subsites is of certain guiding significance for the clinical diagnosis and treatment of colorectal cancer, and is conducive to individualized treatment and accurate treatment. |
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| Keywords: | Colorectal cancer Right-sided colon cancer Left-sided colon cancer Clinicopathological features |
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