Long noncoding RNAs in bladder cancer prognosis: A meta-analysis |
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| Affiliation: | 3. Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;5. Antibody Drug Engineering Laboratory of Henan Province, Henan University School of Medicine, Kaifeng, Henan 475004, China;4. Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia 30912;12. Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia 30912;6. Departments of Dermatology and Internal Medicine, Henry Ford Health System, Detroit, Michigan 48202;1. Department of Medical Oncology, The Sixth People’s Hospital of Yancheng City, No. 66 Tingzhong Road, Yancheng, Jiangsu, 224000, China;2. Department of Oncology, Jimin Hospital, Shanghai, 200052, China;1. Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway;2. Department of Pathology, Oslo University Hospital, Oslo, Norway;3. Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway;4. Department of Informatics, University of Oslo, Oslo, Norway;5. Department of Oncology, Oslo University Hospital, Oslo, Norway;6. Department of Environmental and Health Studies, Faculty of Arts and Sciences, Telemark University College, Telemark, Norway;7. Faculty of Medicine, University of Oslo, Oslo, Norway;1. Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Clinical College of Anhui Medical University, Shenzhen, Guangdong, 518036, PR China;2. Shantou University Medical College, Guangdong, Shantou, 515041, PR China;3. Departments of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, PR China |
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| Abstract: | BackgroundNumerous studies have demonstrated the involvement of long non-coding RNAs (lncRNAs) in the tumorigenesis of bladder cancer (BC). The aim of this study was to investigate the possible correlations between the specific lncRNAs and the clinical outcomes in bladder cancer patients.MethodsWe systematically searched the PubMed, EMBASE and the Cochrane Library databases for studies published up to October 15, 2018, and retrieved the suitable articles. Pooled odds ratios (ORs), hazard ratios (HRs) and 95% confidence intervals (95% CIs) were obtained by using fixed-effect or random-effect model.ResultsUp-regulation of lncRNAs predicted unfavorable overall survival (OS) (HR: 2.01, 95%CI: 1.66–2.44, P < 0.001) and recurrence-free survival (RFS) (HR: 2.05, 95%CI: 1.43–2.94, P < 0.001) in BC patients, and the high expression of lncRNAs was significantly associated with distant metastasis (DM) (OR: 8.16, 95%CI: 4.45–14.99, P < 0.001).ConclusionAbnormal expression of relevant lncRNAs are potential novel markers for predicting the clinical outcomes of BC. |
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| Keywords: | lncRNA Bladder cancer Prognosis Meta-analysis |
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