Idiopathic noncirrhotic portal hypertension |
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| Institution: | 1. Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, Box 1194, The Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029, United States;2. Division of Liver Diseases and Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States;1. Yale School of Medicine, Department of Anatomic Pathology, 20 York Street EP2-608B, New Haven, CT, USA;1. Institute of Liver Studies, King''s College Hospital, London, United Kingdom;2. Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, United States;3. Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States |
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| Abstract: | Cirrhosis is the most common cause of portal hypertension but there are many causes of noncirrhotic portal hypertension. Many of these etiologies may be diagnosed by liver biopsy. Idiopathic noncirrhotic portal hypertension is being increasingly diagnosed and has varied histopathological findings as well as overlapping definitions. Many of these histological changes can be subtle, thus making it a challenging diagnosis for the pathologist to make. This review summarizes the clinical aspects of idiopathic noncirrhotic portal hypertension and outlines the different definitions and histological features of the entity. In addition, pearls and pitfalls for the pathologist in making this diagnosis are included. |
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