Bilateral Optic Disc Swelling Following Anastrozole Therapy |
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| Authors: | Oscar Jim Michael Coppes Rimas V Lukas Gini F Fleming Jeffrey Nichols Meaghan Tenney Jacqueline Bernard |
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| Institution: | aPritzker School of Medicine;bDepartment of Neurology;cSection of Hematology and Oncology;dSection of Ophthalmology;eDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA |
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| Abstract: | A 56-year-old female with early-stage breast cancer, stage IA grade 1 endometrial cancer, and stage IC grade 1 ovarian cancer developed sudden-onset visual changes and right inferior visual field defect following anastrozole therapy. Examination revealed severe bilateral optic disc swelling and impaired visual acuity. Laboratory work-up was otherwise unremarkable. Anastrozole was discontinued and over the next month, patient had near-complete resolution of swelling in the right eye and improvement in the left eye. This is the only reported case of optic disc swelling following anastrozole therapy. |
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| Keywords: | Breast neoplasms chemotherapy optical coherence tomography papilloedema vision |
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