| 小儿特发性血小板减少性紫癜血小板相关抗体、T细胞亚群检测及其临床意义 |
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| 引用本文： | 佟琳如,庞秀英,王建英,董增义,张少燕.小儿特发性血小板减少性紫癜血小板相关抗体、T细胞亚群检测及其临床意义[J].中国小儿血液与肿瘤杂志,1997(1). |
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| 作者姓名： | 佟琳如 庞秀英 王建英 董增义 张少燕 |
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| 作者单位： | 青岛医学院附属医院!266003 |
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| 摘 要： | 本文对1989年9月至1995年2月收治的112例小儿特发性血小板减少性紫癜的血小板相关性抗体、T细胞亚群检测及其临床意义进行了探讨。结果表明：急、慢型无论是OKT3及OKT4+均低于正常对照组，且有显著性差异，P值均＜0．05；而OKT8+与正常对照组相比则较高，P值＜0．025。但是，急、慢两型相比均未见统计学上显差性差异。本文的检测血小板抗体lgG、IgM及IgA，显示均有所增高尤以PAIgG最明显，阳性率达85．7％，与文献报道近似。经治疗10例血小板动态变化，PAIg随着血小板的恢复均下降至正常，呈负相关.
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EXAMINATION AND CLINICAL SIGNIFICANCE OF PLATELET RELATED ANTIBODY AND T LYMPHOCYTIC CELL SUBSETS IN CHILDREN WITH ITP |
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| Abstract: | Peripherial blood T lymphoycytic subsets and platelet related antibody were examined in 112 children with idiopathic thrombocytopenic purpura (ITP). Their clinical significance was observed. The results showed the number of OKT3, OKT4 positive cells reduced and OKTS positive cells elevated and ratio of OKT4/OKT8 reduced when platelet decreased, PAIgG,PAIgM and PAIgA, especially PAIgG alse elevated. When PAIg elevated ratio of OKT4/OKT8 reduced. These showed the change of PAId and OKT4/OKT8 was associated with degree of disease. |
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