| 特发性CD4+T淋巴细胞减少症伴播散性皮肤隐球菌病 |
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| 引用本文： | 高春芳,王英,毕新岭,舒国斌,唐跃琼,李秀凯,顾军. 特发性CD4+T淋巴细胞减少症伴播散性皮肤隐球菌病[J]. 临床皮肤科杂志, 2004, 33(4): 216-218 |
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| 作者姓名： | 高春芳 王英 毕新岭 舒国斌 唐跃琼 李秀凯 顾军 |
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| 作者单位： | 第二军医大学附属长海医院皮肤科,上海,200433;宁波市北仑区宗瑞医院,浙江,宁波,315806 |
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| 摘 要： | 患者女，23岁，左锁骨、腰部右侧及左膝部出现肿块并溃疡4个月，组织病理检查示组织中大量浆细胞及异物巨细胞；PAS染色显示大量散在或成团的孢子，经鉴定证实为新生隐球菌，连续T淋巴细胞亚群分析显示CD4^ T淋巴细胞明显减少，占总T淋巴细胞数20％以下．无人类免疫缺陷病毒(HIV)感染，诊断为特发件CD4^ T淋巴细胞减少症伴播散性皮肤隐球菌病．主要给予两性霉素B治疗，1个月后溃疡愈合．
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| 关 键 词： | CD4+T淋巴细胞减少 特发性 隐球菌病 皮肤 播散性 |
| 文章编号： | 1000-4963(2004)04-0216-01 |
| 修稿时间： | 2003-06-10 |
Idiopathic CD4+T lymphocytopenia in a patient with disseminated skin cryptococcosis |
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| GAO Chun-fang, WANG Yin, BI Xin-ling, SHU Guo-bin, TANG Yue-qiong, LI Xiou-kai, GU Jun,. Idiopathic CD4+T lymphocytopenia in a patient with disseminated skin cryptococcosis[J]. Journal of Clinical Dermatology, 2004, 33(4): 216-218 |
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| Authors: | GAO Chun-fang WANG Yin BI Xin-ling SHU Guo-bin TANG Yue-qiong LI Xiou-kai GU Jun |
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| Abstract: | A 23-year-old woman presented lumps and ulcers on her left clavicle; right loin and left knee areas for 4 months. Large numbers of plasma cells and foreign-body giant cells were shown in histopathologic examination; and PAS staining demonstrated there were scattered and clumped spores; which were identified as Cryptococcus neoformans. T lymphocyte subgroup analysis showed lymphocytopenia ;with reduction of CD4+ lymphocytes; and CD4+ count was less than 20% of the total T cell count. No evidence of human immunodeficiency virus(HIV) infection was found. Idiopathic CD4+T lymphocytopenia with disseminated skin cryptococcosis was diagnosed. Amphotericin B was given to the patient; the ulcers healed after one month. |
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| Keywords: | CD4+T lymphocytopenia idiopathic cryptococcosis disseminated[J Clin Dermatol 2004 33(4):216-218] |
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