| 金喜素联合顺铂治疗晚期非小细胞肺癌56例近期疗效观察 |
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| 引用本文： | 荆新建,任中海,杜敏. 金喜素联合顺铂治疗晚期非小细胞肺癌56例近期疗效观察[J]. 中国全科医学, 2004, 7(20): 1504-1505 |
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| 作者姓名： | 荆新建 任中海 杜敏 |
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| 作者单位： | 1. 450007,河南省郑州市中医院呼吸内科
2. 南阳市中心医院肿瘤科 |
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| 摘 要： | 目的 观察金喜素联合顺铂治疗晚期非小细胞肺癌的近期疗效。方法 金喜素 1mg/m2 ,静脉点滴 ,第 1～ 5d;顺铂 30mg/m2 ,静脉点滴 ,第 1～ 3d。每 2 1d为 1个周期 ,连用 2个周期后评价疗效。结果 CR 5例 ,PR 2 5例 ,总有效率 (CR PR)为 5 3 6 %。本方案主要的副作用是骨髓抑制和胃肠道反应。结论 金喜素联合顺铂是一个安全、有效的治疗晚期非小细胞肺癌的临床方案
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| 关 键 词： | 非小细胞肺癌 药物治疗 |
| 修稿时间： | 2004-06-11 |
A Short-term Observation of Curative Effect of Topotecan and Cisplatin Combined on 56 Cases with Advanced Non-small Cell Lung Cancer |
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| JING Xin-jian,REN Zhong-hai,DU Min. A Short-term Observation of Curative Effect of Topotecan and Cisplatin Combined on 56 Cases with Advanced Non-small Cell Lung Cancer[J]. Chinese General Practice, 2004, 7(20): 1504-1505 |
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| Authors: | JING Xin-jian REN Zhong-hai DU Min |
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| Affiliation: | JING Xin-jian,REN Zhong-hai,DU Min. Department of Respiration,Zhengzhou Hospital of Traditional Chinese Medicine,Zhengzhou 450007,China |
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| Abstract: | Objective To observe the recent effect of combination chemotherapy with topotecan(TPT) and cisplatin(PDD) in the treatment of patients with advanced non-small cell lung cancer.Methods Topotecan(TPT) was 1mg/m 2 iv gtt, d1-5. That of PDD was 30 mg/m 2 iv gtt, d1-3. The schedule was repeated every 21 days, and evaluated after at least two cycles.Results The complete response (CR) was 5 cases, and partial response (PR) was 25 cases. The overall response rate (RR) was 53.6%.The major toxicities of this schedule were myelosuppression and gastrointestinal reaction.Conclusion Combination topotecan and cisplatin is an effective and safe clinical program in the treatment of patients with advanced non-small cell lung cancer. |
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| Keywords: | Non-small cell lung cancer Drug treatment |
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