还原型谷胱甘肽对酒精性肝硬化患者红细胞变形性的影响及疗效观察

目的 观察还原型谷胱甘肽对酒精性肝硬化的治疗效果及对患者红细胞变形性的影响。方法 随机选择30例酒精性肝硬化的住院患者静脉给予还原性谷胱甘肽2．4g治疗2w，对治疗前、后的结果进行比较。结果 治疗后患者的临床症状及肝功能明显改善（ALT，AST，TBil，DBil显著降低，P〈0．01），同时检测平均红细胞体积（MCV）显著降低（P〈0．01），红细胞变形性显著增加（P〈0．05），刚性指数降低（P〈0．05），高切黏度（P〈0．05）和低切黏度（P〈0．01）显著降低。结论 还原性谷胱甘肽对酒精性肝硬化有一定保护作用，保护作用机制可能与其抗脂质过氧化．增加红细胞的变形性，降低血液粘度，进而改善肝脏的微循环，增加肝细胞的供血及供氧有关。

The effect of reduced glutathione on alcoholic cirrhosis and erythrocyte deformability

Objective To investigate the effect of reduced glutathione on patients of alcoholic cirrhosis and observe the change of erythrocyte deformability in them.Methods Thirty in-patients of alcoholic cirrhosis were randomly given reduced glutathione(2.4g) intravenously for 2 weeks,and the parameters of their liver function and hemorheology were compared before and after the treatment.Results The serum ALT,AST,TBil and DBil were significantly decreased(P<0.01)after treatment with the mean corpuscular volume(MCV) significantly decrease(P<0.01) and the erythro-cyte deformability increase(P<0.01).The hemorheological examination also showed that the high shear viscosity(P<0.05) and low shear viscosity(P<0.01) were significantly decreased after treatment.Conclusion Reduced glutathione has protective effect on alcoholic cirrhosis,the mechanism of the effect may be related to the improvement of hepatic microcirculation by the increase of the erythrocyte deformability and the decrease of the blood viscosity.