高尿酸血症与肠道菌群的相关性

最新研究数据表明,我国人群中高尿酸血症患病率已高达13%,且有不断上升及年轻化趋势。尿酸是人体嘌呤代谢的终产物,嘌呤是核酸的氧化分解代谢产物。体内产生的嘌呤在肝脏中再次氧化为(2,6,8-三氧嘌呤),即尿酸,其中2/3尿酸经肾脏随尿液排出体外,1/3通过粪便和汗液排出。近年大量研究表明,肠道菌群的变化与高尿酸血症乃至痛风的发病密切相关,本文就高尿酸血症的发生与肠道菌群的相互关系,及目前研究进展进行综述,进一步探讨尿酸在肠道的代谢机制,旨在为降低血尿酸及治疗尿酸相关疾病提供新的思路。

Relationship between hyperuricemia and intestinal flora

Recent research showed that the prevalence of hyperuricemia in Chinese population was 13%,and it had a rising and younger trend.Uric acid is the end product of purine metabolism and purine is the metabolic product of oxidative decomposition of nucleic acid.The purine produced in vivo is oxidized again to uric acid(2,6,8-trioxine)in the liver,of which 2/3 uric acid is excreted from the kidney with urine and 1/3 is excreted through feces and sweat.In recent years,a large number of studies have shown that the changes of intestinal flora are closely related to the occurrence of hyperuricemia and even gout.In this paper,the relationship between the occurrence of hyperuricemia and intestinal flora is reviewed.The metabolic mechanism of uric acid in intestinal tract is further discussed in order to provide new ideas for reducing serum uric acid and treating uric acid-related diseases.