益生菌联合大黄灌肠治疗急性重症胰腺炎的疗效观察

目的:基于益生菌和大黄灌肠对急性重症胰腺炎(SAP)的疗效,探讨益生菌联合大黄灌肠治疗SAP的价值。方法:选取106例SAP患者,随机分成对照组及试验组,对照组在常规治疗基础上加用大黄灌肠治疗,试验组在常规治疗基础上加用益生菌联合大黄灌肠治疗,对比两组在入院第1天及第14天临床症状改善情况、C反应蛋白(CRP)、降钙素原(PCT)、血淀粉酶水平及并发症情况。结果:试验组腹痛、腹胀、呕吐消失时间、肠鸣音恢复时间均较对照组缩短(P<0.05);试验组CRP、PCT下降程度较对照组更为明显(P<0.05);两组并发症的发生率均降低,试验组低于对照组(P<0.05);两组血淀粉酶下降程度差异不显著(P>0.05)。结论:益生菌联合大黄灌肠可有效改善临床症状,减轻SAP肠黏膜损伤,减少肠源性感染,进而改善预后。

Clinical observation of probiotics combined with rhubarb enema in the treatment of severe acute pancreatitis

Objective:Based on the therapeutic effect of probiotics and rhubarb enema on severe acute pancreatitis(SAP),it was to discuss the effect of rhubarb enema combined with probiotics on SAP.Methods:106 SAP patients were randomly divided into control group and experimental group.The control group were treated with rhubarb enema on the basis of routine treatment,and the experimental group were treated with rhubarb enema combined with probiotics on the basis of routine treatment.The clinical symptoms,C-reactive protein(CRP),procalcitonin(PCT),blood amylase and complications of the two groups were compared on the first and 14th day after admission.Results:The results showed that the disappearance time of abdominal pain,abdominal distention,vomiting and the recovery time of bowel sounds in the experimental group were shorter than those in the experimental group(P<0.05),the decrease degree of CRP and PCT was more obvious(P<0.05),and the incidence of related complications was lower(P<0.05),the decrease degree of serum amylase was not significantly different between the two groups(P>0.05).Conclusion:The method can effectively improve the clinical symptoms,reduce the damage of intestinal mucosa,reduce the incidence of enteric infection,and improve the prognosis of SAP patients.