| IL—6／IL—6R系统介导靶向治疗白血病策略 |
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| 引用本文： | 崔建武. IL—6／IL—6R系统介导靶向治疗白血病策略[J]. 中国实验血液学杂志, 2001, 9(2): 184-187 |
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| 作者姓名： | 崔建武 |
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| 作者单位： | 崔建武（军事医学科学院附属医院免疫学研究室,国家生物医学分析中心免疫分析实验室,北京,100039） 奚永志（军事医学科学院附属医院免疫学研究室,国家生物医学分析中心免疫分析实验室,北京,100039） |
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| 基金项目： | 国家自然科学基金资助课题编号3950006239870875 |
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| 摘 要： | 导向杀伤是治疗白血病的必然趋势，而IL-6/IL-6R系统是细胞因子-受体导向治疗的重要部分，IL-6R在很多肿瘤细胞上都有表达，如多发性骨髓瘤，前列腺癌，白血病等，本文简要综述了IL-6R的表达、IL-6重组毒素融合蛋白抗白血开门见山效应及其对正常造血的作用。
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| 关 键 词： | 白细胞介素6 IL－6R IL－6重组毒素融合蛋白 抗白血病效应 白血病 靶向治疗 |
A Strategy of IL-6/IL-6R System Mediates Targeted Treatment for Leukemia |
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| CUI Jian Wu XI Yong Zhi. A Strategy of IL-6/IL-6R System Mediates Targeted Treatment for Leukemia[J]. Journal of experimental hematology, 2001, 9(2): 184-187 |
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| Authors: | CUI Jian Wu XI Yong Zhi |
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| Abstract: | An inevitable trend for the development of new treatment of leukemia is to use targeted strategy. IL 6/ IL 6R is important one of the cytokine receptor targeted treatment systems. Many malignant cells, including multiple myeloma, prostate carcinoma and leukemia etc., have been shown to express IL 6R. Leukemia cells, especialy in U937, TF1, KG1 cell lines highly express the high affinity IL 6R. IL 6 recombinant toxin is cytotoxic in vitro to leukemia cell expressing high affinity IL 6R; in vivo the fusion toxin can result the reduction of leukemic cell load in animal leukemia model but have no effect on normal hematopoiesis in non leukemic animal. On the basis of these pre clinical studies, IL 6 recombinant toxin my become novel drug for the treatment of leukemia and cancer in future. |
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| Keywords: | IL 6 IL 6R IL 6 recombinant toxin fusion protein anti leukemia effect leukemia targeted treatment |
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