三种不同化疗药物膀胱灌注治疗腺性膀胱炎疗效对比

目的提高对腺性膀胱炎的认识和诊断水平,评价吡柔比星（pirarubicin,THP）,羟基喜树碱（hydroxycamptothecin,HCPT）,丝裂霉素C（mitomycin C,MMC）三种不同药物膀胱灌注治疗腺性膀胱炎的疗效和安全性。方法回顾9年来诊疗、随访的223例患者的临床资料。THP（78例）A组,HCPT（71例）,B组MMC（74例）C组,分别于术后1-2周开始规律膀胱灌注,比较3组患者的治疗效果及副作用。结果随访时间为14个月至9年,平均5年10个月。A组患者的有效率为84.6%,复发率为7.6%;B组患者的有效率为87.3%,复发率为8.5%;C组患者的有效率为86.7%,复发率为9.7%;组之间差异无统计学意义,副作用各组之间差异无统计学意义。结论典型的腺性膀胱炎膀胱镜下肉眼基本能诊断;但确诊多需病理学检查。MMC、THP、HCPT膀胱灌注预防腺性膀胱炎术后复发疗效满意,副作用轻,耐受性良好。

The comparison of the different therapy on female glandular cystitis:report of 223 cases

【Objective】 To evaluate tire procedure of diagnosis and treatment for glandular cystitis,and compare the therapeutic effect and safety of pirarubicin（THP）,Hydroxycamptothec（HCPT）and MitomycinC（MMC） by bladder instillation after transurethral resection of glandular cystitis.【Methods】 233 glandular cystitis cases during the past 9 years were analyzed retrospectively.The symptom and the feature of cystoscope were discussed.According to the treatment procedures,they were divided into 3 groups：group A ：78 cases treated with transurethral resection and followed bladder instillation of THP.group B：71 cases treated with transurethral resection and followed bladder instillation of HCPT,group C：74 cases treated with transurethral resection and followed bladder instillation of MMC,One or two weeks after the TUR2Bt,bladder instillation was performed on all patients regularly.Then the tumor recurrent rates were compared among the three groups,and the effects and side effects were observed.【Results】 All patients were followed up for14months to 9 years,the mean follow-up time was 70 months.The recurrent rate in the THP group,HCPT group and MMC group were 7.6%,8.5% and 9.3%,respectively.There was no different therapeutic effect and side effect among the 3 groups（P〉0.05）.【Conclusion】 Typical glandular cystitis Can be diagnosed by cystoscope.But biopsy is needed.for definite diagnosis.For treating and preventing recurrence of glandular cystitis,transurethral resection followed by bladder instillation with MMC、THP and HCPT had same therapeutic and tolerant effect,side effects were rare.