CD133与肿瘤干细胞靶向治疗

CD133是肿瘤干细胞的表面标记物,在多种实体肿瘤中都有表达,且与肿瘤的化疗抵抗和放疗抵抗有关.CD133作为一种跨膜糖蛋白,其潜在的肿瘤干细胞靶向治疗的分子靶点作用备受关注,有望为肿瘤治疗提供新希望.

CD133 and target therapy of tumor stem cells

CD133 is a stem cell surface antigen that has been recently identified as a potential cancer stem cell marker. CD133 is expressed in many solid tumors and has been associated with tumor resistance to chemotherapy and radiotherapy. As a transmembrane glycoprotein, CD133 received much attention as a molecular marker in targeted therapy of tumor stem cells and will bring new hope to cancer therapy.