氮斯汀喷鼻剂治疗常年性变应性鼻炎随机双盲试验

目的 :探讨氮斯汀喷鼻剂治疗常年性变应性鼻炎的疗效及安全性。方法 :38例中、重度常年性变应性鼻炎病人行随机、双盲、对照研究。分氮斯汀组 19例 ,给予氮斯汀液体喷鼻剂喷鼻 ,每日 2次 ,每次每侧鼻孔 1揿 (每揿 140 μg氮斯汀 ) ,治疗 4wk。左卡巴斯汀组 19例 ,用左卡巴斯汀喷鼻剂喷鼻 ,每日 2次 ,每次 2揿 ,作为对照。治疗 2wk末及 4wk末时 ,根据主观评分及客观检查结果 ,综合评定疗效。结果 :氮斯汀喷鼻剂组总有效率为 95 % ,左卡巴斯汀喷鼻剂组为 84 % (P >0 .0 5 )。 2组治疗前后喷嚏、流涕、鼻痒、鼻塞及眼部症状积分下降分别为 1.4± 0 .8和 1.3± 1.0 ,1.0±0 .7和 0 .8± 0 .9,1.3± 0 .6和 1.4± 0 .7,0 .7± 0 .7和 0 .7± 0 .8,0 .8± 0 .8和 0 .5± 0 .7(均P >0 .0 5 ) ,未发生严重的不良反应。结论 :氮斯汀喷鼻剂与左卡巴斯汀喷鼻剂在治疗常年性变应性鼻炎时具相似的疗效和安全性

Azelastine nasal spray in treating perennial allergic rhinitis: a randomly double-blind trial

AIM: To evaluate the therapeutic efficacy and safety of azelastine nasal spray in treating perennial allergic rhinitis. METHODS: Thirty-eight patients with moderate to severe perennial allergic rhinitis were qualified for the random, double-blind, comparative research. They were divided into two groups: azelastine group (nineteen patients) was treated with azelastine nasal spray, one puff per nostril twice daily for 4 wk (one puff=140 μg azelastine), and levocabastine group (nineteen patients) was treated with levocabastine nasal spray 2 puff per nostril twice daily as the control. At the end of 2 wk and 4 wk treatment, the comprehensine evaluation of effect was made according to the subjective symptom score and objective examination. RESULTS: The total effect rate was 95 %, and 84 %, in azelastine group and in the levocabastine group, respectively (P> 0.05). The differences of symptom score (pre-treatment score-post-treatment score) of sneezing, discharge, itching of nose and nasal blockage between the two groups decieased and those were 1.4±0.8 and 1.3±1.0, 1.0±0.7 and 0.8±0.9, 1.3±0.6 and 1.4±0.7, 0.7±0.7 and 0.7±0.8, 0.8±0.8 and 0.5±0.7, respectively (P>0.05). No remarkable adverse reaction was observed. CONCLUSION: Azelastine nasal spray has similar therapeutic efficacy and tolerability to levocabastine nasal spray in the treatment of perennial allergic rhinitis.