| 拉米夫定治疗e抗原阳性慢性乙型肝炎的近期疗效观察 |
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| 引用本文： | 刘仁志,夏璀,邬艳波. 拉米夫定治疗e抗原阳性慢性乙型肝炎的近期疗效观察[J]. 医疗保健器具, 2011, 18(12): 1890-1891. DOI: 10.3969/j.issn.1674-4659.2011.12.1890 |
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| 作者姓名： | 刘仁志 夏璀 邬艳波 |
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| 作者单位： | 深圳市观澜人民医院,广东深圳,518110 |
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| 摘 要： | 目的 HBsAg定量预测法观察拉米夫定治疗e抗原阳性慢性乙型肝炎（CHB）的近期疗效。方法根据患者血清中HBsAg水平将48例CHB患者分为三个治疗组,分别为HBsAg〈100、100～200及〉200ng/L,每组各16例,治疗组给予拉米夫定抗病毒治疗,对照组10例CHB患者给予常规保肝对症治疗,不采取拉米夫定治疗。治疗4周时观察两组的e抗原血清转换率及HBV DNA阴转率。结果三个拉米夫定治疗组患者的各项指标均明显优于对照组（P〈0.05）;其中治疗A组患者恢复情况明显优于其它各组（P〈0.05）。结论 HBsAg初始水平及近期疗效是预测e抗原血清转换率的两项较好指标,对于拉米夫定的临床用药具有指导作用。
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| 关 键 词： | e抗原 慢性乙型肝炎 拉米夫定 HBsAg定量预测 近期疗效 |
The Short-term Efficacy Observation of the Treatment of E Antigen-positive Chronic Hepatitis B by Lamivudine |
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| LIU Renzhi,XIA Cui,WU Yanbo. The Short-term Efficacy Observation of the Treatment of E Antigen-positive Chronic Hepatitis B by Lamivudine[J]. Medicine Healthcare Apparatus, 2011, 18(12): 1890-1891. DOI: 10.3969/j.issn.1674-4659.2011.12.1890 |
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| Authors: | LIU Renzhi XIA Cui WU Yanbo |
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| Affiliation: | LIU Renzhi,XIA Cui,WU Yanbo (Shenzhen Gunlan People's Hospital of Shenzhen,Shenzhen 518110,China) |
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| Abstract: | Objective To observe the short-term effect of lamivudine treatment of e antigen-positive chronic hepatitis B(CHB) by HBsAg quantitative prediction method. Methods 48 cases of CHB patients were divided into three treatment groups according to the level of serum HbsAg: HBsAg <100, 100 ~ 200 and >200 ng/L. There were 16 cases in each group; the treatment group were treated with lamivudine antiviral therapy. 10 patients with CHB of control group were treated with conventional liver symptomatic treatment, withou... |
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| Keywords: | E antigen Chronic Hepatitis B Lamivudine HBsAg quantitative prediction Short-term efficacy |
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