CD4+ T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells |
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Authors: | Filippi Christophe Hugues Stephanie Cazareth Julie Julia Valerie Glaichenhaus Nicolas Ugolini Sophie |
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Institution: | E03-44, Institut National de la Santé et de la Recherche Médicale, University of Nice-Sophia Antipolis, 660 Route des Lucioles, 06560 Valbonne, France. |
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Abstract: | Resistance and susceptibility to Leishmania major in mice are determined by multiple genes and correlate with the preferential development of Th1 and Th2 responses, respectively. Here, we found that CD11b+ dendritic cells (DCs) prime parasite-specific CD4+ T cells in both susceptible BALB/c (H2-d) and resistant B10.D2 (H2-d) mice. However, BALB/c and B10.D2 DCs from L. major-infected mice differ in their ability to polarize naive T cells into Th1 or Th2 effector cells. This difference is cell-intrinsic, is not restricted to H2-d mice, and is observed with both parasite-specific and allospecific CD4+ T cells. Thus, strain-specific differences within CD11b+ DCs influence the ability of inbred mice to mount polarized CD4+ T cell responses. |
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