冠状动脉支架术对兔凝血和血小板功能影响的实验研究

为探讨冠状动脉支架对兔凝血功能和血小板功能的影响，18只雄性新西兰兔经冠状动脉支架植入术，分别于术前和术后1、2、4、24h各时间点采血后，分别测定凝血功能指标：凝血酶时间(TT)，凝血酶原时间(PT)，活化部分凝血活酶时间(APTT)，和血浆中纤维蛋白原(fg)、P-选择素和血栓烷B2(TXB2)的含量，同时测定血小板的聚集功能和血小板数量。结果表明在使用支架前后，TT、PT、APTT无明显差异，但是术后血浆中Fg和血小板数水平逐渐下降，24h后恢复到正常水平，术后1h血小板聚集率和血浆中释放P-选择素、TXB2的含量显著增高。结果提示冠状动脉支架术对兔的血小板活化、血栓的形成和凝血系统活化有明显影响，同时证实了冠状动脉支架术后，监测血小板活化程度和抗栓治疗的必要性。

Effect of Coronary Stent Implantation on Coagulation and Platelet Function of Rabbits

To study the effect of coronary stent implantation on the coagulation and platelet function of rabbits, eighteen New Zealand white male rabbits were underwent precutaneous transluminal coronary stenting. Their blood samples were collected before and at 1, 2, 4, 24 hour after the stent implantation, respectively. The coagulant parameters of thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT) and the fibrinogen, P-Selectin and thromboxane B2 (TxB2) level in plasma, platelet number, and tested platelet aggregation function were detected. The coagulation parameters of TT, PT, APTT had no significant change after the stent implantation, but the platelet number and the fibrinogen level in plasma was decrease after stent implantation and came back to the normal level in the 24 hour after the surgery. The level of platelet aggregation rate and P-Selectin and TxB2 in plasma was higher after the stent implantation. Therefore, the coronary stent implantation had significant effect on the platelet activation , thrombosis and the activation of congulant system, It was approved that it is necessary to inspect the platelet activation and therapy with antithrombotic medicine after the stent implantation simultaneously.