视网膜色素变性的黄斑局部视网膜电图频谱分析

目的 通过对黄斑局部视网膜电图（ＬＥＲＧ）的Ｆｏｕｒｉｅｒ分析，进一步了解视网膜色素变性（ＲＰ）患者黄斑部光感受器细胞与光感受器后神经元细胞功能异常的情况。方法 ４９例ＲＰ患者的ＩＥＲＧ被记录研究。应用手提眼底镜式局部刺激器通过放大的瞳孔直视眼底监控固视状况，闪烁光频率３１Ｈｚ。结果 与对照组相比，ＬＥＲ的基波（ｆｕｎｄａｍｅｎｔａｌ ｈａｒｍｏｎｉｃ，ｉｆ）与二次谐波（ｓｅｃｏｎｄ ｈａｍｏｎｉ

Fourier analysis of macular local electroretinogram in retinitis pigmentosa

Objective To understand the sites of macular dysfunction in retinitis pigmentosa (RP) by evaluating local electroretinogram (LERG) and further evaluating fundamental and second harmonic components. Methods LERG were recorded in 98 eyes of 49 patients to a flickered sinusoid of 31Hz and 10Hz with a hand held stimulator with direct visualization of the fundus through dilated pupils. Results Compared to controls, the patients showed losses of both fundamental and second harmonic amplitudes. The abnormality ratios of fundamental amplitudes in RP affected time <5 years,5 15 years,15 25 years and >25 years were 54%, 64%, 83% and 92% respectively; and the abnormality ratios of second harmonic amplitudes were 18%, 36%, 58% and 75% respectively. The fundamental second harmonic ratio was much more higher in the autosomal recessive and sporadic patients than in the autosomal dominant patients ( P <0.01). On average, the fundamental second harmonic ratio in the patients tended to increase with age. Conclusion The results suggest that in the retinitis pigmentosa, both receptoral and postreceptoral sites contribute to macular dysfunction. The level of macular dysfunction in different types of hereditary patients is different. It would be of clinical value to obtain a fundamental second harmonic ratio in order to assess the disturbance in different sites of macular.