Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs |
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Authors: | Giunchetti Rodolfo Cordeiro Corrêa-Oliveira Rodrigo Martins-Filho Olindo Assis Teixeira-Carvalho Andréa Roatt Bruno Mendes de Oliveira Aguiar-Soares Rodrigo Dian de Souza Juliana Vitoriano das Dores Moreira Nádia Malaquias Luiz Cosme Cotta Mota e Castro Luciana Lisboa de Lana Marta Reis Alexandre Barbosa |
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Institution: | Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas/NUPEB, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil. giunchetti@nupeb.ufop.br |
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Abstract: | Cellular and humoral immune responses of dogs to a candidate vaccine, composed of Leishmania braziliensis promastigote protein plus saponin as adjuvant, have been investigated as a pre-requisite to understanding the mechanisms of immunogenicity against canine visceral leishmaniasis (CVL). The candidate vaccine elicited strong antigenicity related to the increases of anti-Leishmania IgG isotypes, together with higher levels of lymphocytes, particularly of circulating CD8(+) T-lymphocytes and Leishmania chagasi antigen-specific CD8(+) T-lymphocytes. As indicated by the intense cell proliferation and increased nitric oxide production during in vitro stimulation by L. chagasi soluble antigens, the candidate vaccine elicited an immune activation status potentially compatible with effective control of the etiological agent of CVL. |
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