孤独症危险因素探讨

目的:探讨孤独症的危险因素及其在孤独症发病中的作用。方法:选取孤独症儿童138名,与年龄、性别相匹配的138名身体健康、智力正常的儿童进行病例对照研究。统计方法采用t检验、χ2检验和非条件多因素Logistic回归分析,采用SPSS13.0统计软件进行数据处理。结果:χ2检验显示父母的文化程度、母亲先兆流产、孕早期感冒、是否正常孕周、缺氧窒息、高热惊厥、遗传史和母亲性格内向有统计学意义;非条件多因素回归分析结果显示,对孤独症发病的贡献值从大到小依次为遗传史、先兆流产、孕早期感冒、父亲的文化程度、产期异常、母亲的性格内向。结论:母亲孕产期并发症、患者长期重病、家庭情况、遗传史等均可能是孤独症的危险因素,尤其是遗传史及母亲的先兆流产与孤独症发病的关系最为密切。控制以上危险因素可能有助于预防和降低孤独症的发生率。

Analysis of Risk Factors in Patients with Autism

Objective:To explore potential prenatal,perinatal,neonatal,developmental and family risk factors of autism trough case-control study. Methods:138 children with autism(DSM-IV criteria) who come from a special autistic school and 138 normal children who come from the normal school matching by sex and age were investigated respectively.We analyze these data by t-test、 χ~2 test and unconditional logistic regression.Results: There were significant association between autism and culture level of parents,threatened abortion,Influenza,pregnant week,neonate suffocates,convulsions,hereditary disease history,mother character.Conclusion:The unfavorable events in pregnant,delivery,the neonatal and developmental phase increase the risk of autism.We should take some effective to control these risk factors.