晶珠肝泰舒对大鼠实验性肝损伤的影响

目的研究藏药晶珠肝泰舒对实验性纤维化大鼠的影响。方法 60只Wistar大鼠随机分为正常对照组、模型组、联苯双酯滴丸对照组和晶珠肝泰舒高、中、低剂量组,采用CCl4诱导大鼠肝纤维化模型,晶珠肝泰舒高、中、低剂量组和联苯双酯滴丸组的大鼠自造模次日起灌胃给药,连续42 d,测定肝脏中羟脯氨酸、肝胶原蛋白和血清中血脂的含量。结果晶珠肝泰舒能降低肝纤维化大鼠肝脏中羟脯氨酸、肝胶原蛋白及血清中TCH、TG含量。结论晶珠肝泰舒对大鼠的实验性纤维化有显著疗效。

Influence of Gantaishu capsules on biochemical criteria of experimental hepatic injury in rats

OBJECTIVE To study the influence of Gantaishu capsules on the biochemical criteria of experimental hepatic fibrosis in rats.METHODS Wistar rats were randomized into the control group,the model group,the positive control group and the Gantaishu capsules group of high,medium,low dosages.A hepatic fibrosis model on rats was set up with CCl4(40%).From the 2nd day of modeling,the groups were given through gastrogavage Gantaishu capsules of high,medium,low dosages,as well as Bifendate guttae,for 42 consecutive days.Except for the control group,all other groups were fed with high-fat fodders.After the last administration,the contents of hydroxyproline and collagen in the livers,and the content of blood fat in the serum were identified.RESULTS The contents of hydroxyproline and collagen in all groups were obviously lower than those in the model group.The contents of TCH and TG in serum of all groups were decreased,with a significant difference between the Gantaishu capsules group of high,medium dosages and the model group(P<0.01).CONCLUSION Gantaishu capsules might have a significant therapcutic effect on experimental hepatic fibrosis in rats.