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| 棓丙酯脂质体的制备与表征 | |
| 引用本文： | 谢运飞,王建新,茹歌,韩丽妹,陆静冉,秦晶,陈大为.棓丙酯脂质体的制备与表征[J].华西药学杂志,2012,27(1):64-66. |
| 作者姓名： | 谢运飞 王建新 茹歌 韩丽妹 陆静冉 秦晶 陈大为 |
| 作者单位： | 1. 复旦大学药学院,上海201203;沈阳药科大学药学院,辽宁沈阳110016 2. 复旦大学药学院,上海,201203 3. 上海工程技术大学化学化工学院,上海,201620 4. 沈阳药科大学药学院,辽宁沈阳,110016 |
| 基金项目： | 上海市科委-联合利华研究与发展基金 |
| 摘 要： | 目的制备棓丙酯脂质体,并对其进行理化性质的表征和释放度的评价。方法采用薄膜分散法制备棓丙酯脂质体,超滤离心法测定脂质体的包封率,正交设计优化处方,并对其包封率、粒径、Zeta电位、形态及体外释放行为进行综合评价。结果正交设计优化最终处方为磷脂浓度5 mg.mL-1、药脂比1∶5、磷脂胆固醇比5∶1、水化介质离子强度20 mmol.mL-1,所得脂质体包封率为89.6%、粒径为181.3 nm、Zeta电位为-21.8 mV、4 h体外释放达到80%。结论制备的棓丙酯脂质体包封率高,粒径小而均一,体外释放完全。 |
| 关 键 词： | 棓丙酯 脂质体 包封率 体外释放 |
Preparation and in vitro characterization of Propylgallate liposomes |
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| XIE Yun-fei , WANG Jian-xin , RU Ge , HAN Li-mei , LU Jing-ran , QIN Jing , CHEN Da-wei.Preparation and in vitro characterization of Propylgallate liposomes[J].West China Journal of Pharmaceutical Sciences,2012,27(1):64-66. | |
| Authors: | XIE Yun-fei WANG Jian-xin RU Ge HAN Li-mei LU Jing-ran QIN Jing CHEN Da-wei |
| Institution: | 1.School of Pharmacy,Fudan University,Shanghai,201203 P.R.China;2.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,Liaoning,110016 P.R.China;3.College of Chemistry and Chemical Engineering,Shanghai University of Engineering Science,Shanghai,201620 P.R.China) |
| Abstract: | OBJECTIVE To prepare and characterize Propylgallate(PG) liposomes.METHODS PG liposome was prepared by film dispersion method and ultrafiltrate centrifugation method was used to determine encapsulation efficiency.RESULTS The optimized formulation parameters included:the concentration of soybean lecithin(SPC) 5 mg·mL-1,PG-SPC(1:5),SPC-cholesterol(5:1),ionic strength 20 mmol·L-1.The particle diameter was 181.3 nm and Zeta potential was-21.8 mV.The cumulative of release amount was up to 80% within 4 h.CONCLUSION PG liposomes are of high encapsulation efficiency with a small and uniform particle size. |
| Keywords: | Propylgallate Liposome Preparation Characterization Encapsulation efficiency |
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