| 阿魏酸、川芎及复方脑得生中阿魏酸在大鼠体内的药动学研究 |
| |
| 引用本文： | 欧阳臻,潘璐琳,汤建明,杨雨,王博. 阿魏酸、川芎及复方脑得生中阿魏酸在大鼠体内的药动学研究[J]. 中国中药杂志, 2010, 35(2): 226-228 |
| |
| 作者姓名： | 欧阳臻 潘璐琳 汤建明 杨雨 王博 |
| |
| 作者单位： | 江苏大学药学院,江苏,镇江,212013 |
| |
| 基金项目： | 江苏大学高级专业人才科研启动基金(06JDG042) |
| |
| 摘 要： | 目的:建立RP-HPLC测定大鼠血浆中阿魏酸浓度的方法,研究阿魏酸、川芎及复方脑得生片中阿魏酸的药动学特点,评价中药材中其他成分和复方中其他配伍对阿魏酸药动学的影响.方法:大鼠分别灌胃给予阿魏酸对照品、川芎药材提取物、复方脑得生片,断尾采血,离心,取血浆适量,加甲醇沉淀蛋白,取上清液过滤,用HPLC分析,以C_(18)为固定相,流动相为甲醇-0.5%醋酸水溶液(30:70),在320 nm检测阿魏酸血药浓度,3p97软件处理数据.结果:阿魏酸血浆在0.05～1 mg·L~(-1)线性关系良好,血浆中最低检测质量浓度为13μg·L~(-1).大鼠灌胄给予阿魏酸对照品、川芎提取物和脑得生片后的药-时曲线均符合二房室模型,主要药动学参数AUC_(0～t),C_(max),CL在阿魏酸对照品、川芎提取物和脑得生片各组间均有统计学意义.结论:本实验建立的RP-HPLC测定法,专属、准确、灵敏,适用于阿魏酸在大鼠体内的药动学研究.川芎药材中的其他组分会影响阿魏酸的口服吸收,而复方配伍后可促进川芎中阿魏酸的吸收,提高阿魏酸的生物利用度.
|
| 关 键 词： | 阿魏酸 川芎 脑得生片 药动学 高效液相色谱法 |
| 收稿时间： | 2008-12-23 |
Studies on pharmacokinetics of ferulaic acid, Rhizoma Chuanxiongand Naodesheng capsule in rat |
| |
| OU Yangzhen,PAN Lulin,TANG Jianming,YANG Yu and WANG Bo. Studies on pharmacokinetics of ferulaic acid, Rhizoma Chuanxiongand Naodesheng capsule in rat[J]. China Journal of Chinese Materia Medica, 2010, 35(2): 226-228 |
| |
| Authors: | OU Yangzhen PAN Lulin TANG Jianming YANG Yu WANG Bo |
| |
| Affiliation: | College of Pharmaceutical, Jiangsu University, Zhenjiang 212013, China;College of Pharmaceutical, Jiangsu University, Zhenjiang 212013, China;College of Pharmaceutical, Jiangsu University, Zhenjiang 212013, China;College of Pharmaceutical, Jiangsu University, Zhenjiang 212013, China;College of Pharmaceutical, Jiangsu University, Zhenjiang 212013, China |
| |
| Abstract: | Objective: To establish a RP-HPLC method to determine the pharmacokinetics of ferulaic acid of ferulaic acid,Rhizoma Chuanxiong extraction and Naodesheng capsule in rat and assess the effect of other components in medical material and in compound on the pharmacokinetics of ferulaic acid.Method: The rats were orally treated with referential ferulaic acid,Rhizoma Chuanxiong extraction and Naodesheng capsule repectively.Blood samples were collected by cutting rats tails.Plasma was separated by centrifugation a... |
| |
| Keywords: | ferulaic acid Rhizoma Chuanxiong Naodesheng pharmacokinetics HPLC |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
