| 莫沙比利治疗老年2型糖尿病胃轻瘫的临床疗效 |
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| 引用本文： | 张赣生,陈洁,赵尚敏,于晓峰,黄海,唐熙,姚健凤. 莫沙比利治疗老年2型糖尿病胃轻瘫的临床疗效[J]. 中国临床药学杂志, 2010, 0(4): 199-201 |
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| 作者姓名： | 张赣生 陈洁 赵尚敏 于晓峰 黄海 唐熙 姚健凤 |
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| 作者单位： | 复旦大学附属华东医院消化科;复旦大学附属华东医院核医学科; |
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| 摘 要： | 目的观察莫沙比利对老年2型糖尿病胃轻瘫的临床疗效。方法采用随机单盲对照试验。将80例老年糖尿病胃轻瘫患者随机分成2组，莫沙比利组40例，予莫沙比利5mg，rid，餐前服用；对照组40例，予安慰剂餐前服用。疗程为12个月。2组患者在入选时及治疗期间每3个月测定空腹血糖（FBG）和餐后2h血糖（PBG），在入选时和疗程结束时行胃排空试验。结果2组患者经治疗后FBC均比治疗前有所下降，且随着治疗时间的延长，FBG值越低；PBG也均比治疗前有所下降，但差异无统计学意义（P〉0．05）。莫沙比利组治疗后胃半排空时间较治疗前明显降低[（82．35±12．64）min vs （103．80±22．24）min，P〈0．05]；而对照组治疗前后差异未见有统计学意义（P〉0．05）。结论莫沙比利能改善部分老年糖尿病胃轻瘫患者胃排空功能，有利于控制血糖。
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| 关 键 词： | 老年 2型糖尿病 莫沙比利 胃轻瘫 血糖 胃半排空时间 |
Clinical therapeutic effect of mosapride on gastroparesis in geriatric type 2 diabetic patients |
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| ZHANG Gansheng,CHEN Jie,ZHAO Shangmin,YU Xiaofeng,HUANG Hai,TANG Xi,YAO Jianfeng. Clinical therapeutic effect of mosapride on gastroparesis in geriatric type 2 diabetic patients[J]. Chinese Journal of Clinical Pharmacy, 2010, 0(4): 199-201 |
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| Authors: | ZHANG Gansheng CHEN Jie ZHAO Shangmin YU Xiaofeng HUANG Hai TANG Xi YAO Jianfeng |
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| Affiliation: | ZHANG Gansheng1,CHEN Jie1,ZHAO Shangmin1,YU Xiaofeng1,HUANG Hai1,TANG Xi2,YAO Jianfeng1(1Department of Gastroenterology,2Department of Nuclear Medicine,Huadong Hospital,Fudan University,Shanghai 200040,China) |
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| Abstract: | AIM To observe the clinical effect of mosapride on gastroparesis in geriatric type 2 diabetic patients.METHODS By using randomized,single blind control and open trial,eighty geriatric type 2 diabetic patients were divided into mosapride group(n=40) and control group(n=40) randomly.Mosapride and placebo were administrated 30 min before meals during one year.Each of the patients was monitored the gastric half emptying time(GET1/2) of solid meals radiolabelled with 99m Tc by nucleology at the beginning and the... |
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| Keywords: | elderly type 2 diabetes mellitus mosapride gastroparesis blood glucose gastric half emptying time |
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