| 急性冠脉综合征患者中氯吡格雷抵抗的发生率及影响因素 |
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| 引用本文： | 王明亮,朱毅,甘洁民. 急性冠脉综合征患者中氯吡格雷抵抗的发生率及影响因素[J]. 中国临床药学杂志, 2010, 0(3): 142-144 |
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| 作者姓名： | 王明亮 朱毅 甘洁民 |
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| 作者单位： | 上海市普陀区人民医院心内科;复旦大学附属华东医院心内科;复旦大学附属华东医院检验科; |
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| 摘 要： | 目的探讨急性冠状动脉综合征（ACS）患者中氯毗格雷抵抗（CPGR）的发生率及影响因素。方法入选100例拟行经皮冠状动脉介入治疗（PCI）的ACS患者，服用负荷量氯吡格雷（CPG）前、服药后24h分别采血，利用光比浊法测定血浆二磷酸腺苷（ADP）诱导的血小板聚集率（PA），根据PA抑制程度判断CPGR发生率，并据此分为CPGR组和非CPGR组。对ACS患者临床危险因素与CPGR进行相关分析。结果100例ACS患者中有23例发生CPGR，CPGR发生率为25％。CPGR组和非cPGR组在基线临床特征和合并用药方面差异均无统计学意义（P〉0．05）。但CPGR组基线PA明显低于非CPGR组（P〈0．05），基线PA是CPGR的独立预测指标。结论ACS和PCI术后抗血小板治疗中，部分患者确实存在CPGR现象。基线PA水平对CPGR具有重要的预测价值。
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| 关 键 词： | 急性冠脉综合征 氯吡格雷 药物抵抗 血小板聚集率 影响因素 |
Incidence rates of clopidogrel resistance and influential factors in patients with acute coronary syndrome |
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| WANG Mingliang,ZHU Yi,GAN Jiemin. Incidence rates of clopidogrel resistance and influential factors in patients with acute coronary syndrome[J]. Chinese Journal of Clinical Pharmacy, 2010, 0(3): 142-144 |
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| Authors: | WANG Mingliang ZHU Yi GAN Jiemin |
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| Affiliation: | WANG Mingliang~1,ZHU Yi~2,GAN Jiemin~3(1 Department of Cardiology,Shanghai Putuo District People's Hospital,Shanghai 200060,China,2 Department of Cardiology,3 Department of Clinical Laboratory,Huadong Hospital Affiliated with Fudan University,Shanghai 200040,China) |
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| Abstract: | AIM To observe the prevalence and probable influential factors of clopidogrel resistance(CPGR) in patients with acute coronary syndrome(ACS).METHODS One hundred patients with ACS undergoing percutaneous coronary intervention(PCI) were enrolled.Using light tiansmittance aggregometry,platelet aggregation(PA) induced by adenosine diphosphate(ADP) was measured before and 24 h after loading dose clopidogrel intake.All the patients were divided into CPGR group and clopidogrel sensitive group according to the degr... |
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| Keywords: | acute coronary syndrome clopidogrel drug resistance platelet aggregation influential fector |
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