| 甾体皂苷化合物抑制血栓形成作用的研究 |
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| 引用本文： | 邓云,马百平,徐秋萍,熊呈琦,张爱林,赵阳,吴彦.甾体皂苷化合物抑制血栓形成作用的研究[J].军事医学科学院院刊,2004,28(3):215-217,220. |
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| 作者姓名： | 邓云 马百平 徐秋萍 熊呈琦 张爱林 赵阳 吴彦 |
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| 作者单位： | 1. 北京中医药大学药理教研室,北京,100102
2. 军事医学科学院放射医学研究所,北京,100850 |
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| 基金项目： | 首都“2 48”工程重大创新工程项目 ( 95 5 0 2 13 40 0 )，国家自然科学基金面上项目 ( 3 0 0 70 93 1) |
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| 摘 要： | 目的：观察甾体皂苷化合物(化合物9714)对血栓形成、血小板聚集及血液流变学的影响。方法：采用动静脉旁路血栓形成模型，测定化合物9714对血栓形成的影响；采用比浊法，测定其对大鼠血小板聚集的影响；采用大鼠急性血淤模型，测定其对血液流变学的影响。结果：化合物971410，20，40mg／kg组均能明显减轻血栓的干重及湿重；可抑制ADP、胶原诱导的大鼠血小板聚集；降低急性血淤大鼠的全血黏度、血浆黏度、红细胞聚集性，以及增强红细胞变形性。结论：化合物9714通过抑制血小板聚集、改善血液流变学来发挥其抗血栓形成作用。
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| 关 键 词： | 化合物9714 动静脉旁路血栓 血小板聚集 血液流变学 |
| 文章编号： | 1000-5501(2004)03-0215-04 |
Antithrombotic effect of a steroidal saponin |
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| DENG Yun ,MA Bai-Ping ,XU Qiu-Ping ,XIONG Cheng-Qi ,ZHANG Ai-Lin ,ZHAO Yang ,WU Yan.Antithrombotic effect of a steroidal saponin[J].Bulletin of the Academy of Military Medical Sciences,2004,28(3):215-217,220. |
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| Authors: | DENG Yun MA Bai-Ping XU Qiu-Ping XIONG Cheng-Qi ZHANG Ai-Lin ZHAO Yang WU Yan |
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| Institution: | DENG Yun 1,MA Bai-Ping 2*,XU Qiu-Ping 1,XIONG Cheng-Qi 2,ZHANG Ai-Lin 1,ZHAO Yang 2,WU Yan 1 |
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| Abstract: | Objective: To study the effects of the steroidal saponin (compound 9714) on thrombosis, platelet aggregation and hemorheology. Methods: Arteriovenous shunt thrombosis was used to measure thrombosis, turbidimetry was used to measure platelet aggregation, acute blood stasis model was used to measure hemorheology. Results: Compound 9714 10,20,40mg/kg ig markedly decreased both wet weight and dry weight of thrombus, inhibited platelet aggregation induced by ADP and collagen, reduced the whole blood viscosity and plasma viscosity, reduced erythrocyte aggregation and improved erythrocyte deformability in rats. Conclusion: Compound 9714 could obviously inhibit the formation of thrombus through inhibition of platelet aggregation and improvement of hemorheology in rats. |
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| Keywords: | compound 9714 arteriovenous shunt thrombosis platelet aggregation hemorheology |
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