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Infection of donor lymphocytes with human T lymphotrophic virus type 1 (HTLV-I) following allogeneic bone marrow transplantation for HTLV-I positive adult T-cell leukaemia |
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| Authors: | Per Ljungman Mark Lawler Birgitta Åsjo Gordana Bogdanovic Karin Karlsson Claes Malm Shaun R McCann Olle Ringdén Gösta Gahrton |
| Institution: | Departments of Medicine, Clinical Immunology and Transplantation Surgery, Huddinge University Hospital and Karolinska Institute, Huddinge, Sweden;Department of Haematology, University Hospital, Linköping, Sweden;Department of Virology, Swedish Institute for Infectious Disease Control, Stockholm, Sweden;Department of Microbiology and Immunology, University of Bergen, Norway.;Department of Genetics, Trinity College, Dublin, Ireland;Department of Clinical Haematology and Oncology, St James Hospital and Trinity College, Dublin, Ireland |
| Abstract: | Summary. Human T lymphotrophic virus type 1 (HTLV-I) associated leukaemia has a poor prognosis even with chemotherapy. We describe a patient with adult T-cell leukaemia treated with allogeneic bone marrow transplantation from an HTLV-I negative identical sibling donor. During follow-up after bone marrow transplantation, HTLV-I could be repeatedly isolated inspite of anti-viral prophylaxis. The patient died of an acute encephalitis and HTLV-I could be detected in autopsy material from the brain. By a PCR-based technique using short tandem repeats (STRs) it was shown that the patient's haemopoiesis was of donor origin. This shows the infection of donor cells in vivo by an aetiological agent which has been implicated in the leukaemogenic process for adult T-cell leukaemia. |
| Keywords: | HTLV-I adult T-cell leukaemia BMT PCR relapse |