后纵膈恶性蝾螈瘤的临床病理分析

目的探讨恶性蝾螈瘤的病理学表现、免疫组化特点和遗传学改变。方法回顾分析1例罕见恶性蝾螈瘤患者的临床资料,并复习相关文献。结果患者胸片和CT检查均示胸腔内巨大占位。手术发现肿块位于后纵膈。病理学检查发现,肿瘤由梭形细胞组成,细胞异型性明显,部分细胞胞浆丰富,嗜伊红;免疫组化结果显示,肿瘤细胞呈myoglobin、desmin和S-100阳性反应。病理诊断为后纵隔恶性蝾螈瘤。结论发生于纵膈的恶性蝾螈瘤十分罕见,其缺乏特征性的临床和影像学表现,诊断主要依靠病理学检查和免疫组化检测。

Clinicopathological analysis of malignant triton tumor of the posterior mediastinum

Objective To investigate the pathologic appearances,immunohistochemical features,and genetic changes of malignant triton tumor(MTT). Methods One case of MTT was studied pathologically and immunohistochemically,and the related literatures were reviewed. Results A huge mass,demonstrated in the thorax by X ray and CT scan was seen in the posterior mediastinum in the surgery.Histologically,the tumor was composed of spindle cells with significant atypia.Some of the tumor cells had dense eosinophilic cytoplasm.Immunohistochemical staining revealed positive for myoglobin,desmin and S-100 in most of the tumor cells.The pathological diagnosis was MTT of the posterior mediastinum. Conclusion Cases of MTT in the mediastinum are very rare,with less specific clinical and imaging manifestations.The diagnosis is mainly made on the basis of pathological examination and immunohistochemical staining.