原发性乳腺癌HER-2与P53蛋白表达的相关性研究

目的探讨HER-2与P53蛋白表达在乳腺癌中表达的相关性及临床意义。方法天津市肿瘤医院2002年7月至2005年11月住院治疗的2996例原发性乳腺癌,年龄15～92岁,中位50岁。均经手术切除病理组织学证实。采用免疫组化sP法进行雌激素受体（ER）,孕激素受体（PR）,表皮生长因子受体2（HER-2）及P53蛋白检测。相关性计算采用卡方检验进行数据差异性分析,采用多元逐步回归进行多因素分析计算。结果HER-2过表达阴性者2316例（77．3％）,HER-2过表达阳性者680例（22．7％）,其中HER-2过表达弱阳性（＋＋）378例（12．6％）,强阳性（＋＋＋）302例（10．1％）。P53阳性者935例,P53阴性者2061例。HER-2过表达阳性在P53阳性中占32．2％,在P53阴性中占18．4％（P〈0．01）。多因素统计学分析显示HER-2表达与P53表达呈正相关（P〈0．01）,即p53表达阳性时,HER-2过表达阳性率增加。结论乳腺癌P53的表达水平是HER-2表达的独立影响因素。

Correlation of expression of epidermal growth factor receptor-2 expression and tumor marker p53 in primary breast cancer

OBJECTIVE: To observe the correlation between expression of epidermal growth factor receptor (HER)-2 and tumor marker p53 in breast cancer. METHODS: specimens of primary breast cancer were collected from 2996l patients, all female, aged 50 (15 - 92). All of the cases were confirmed by pathohistological method. Immunohistochemistry was used to detect the expression of estrogen receptor (ER), progesterone receptor (PR), Her-2, and p53. RESULTS: 680 cases (22.7%) showed HER-2 overexpression, among which 378 cases (12.6%) were HER-2 weak positive (++) and 302 cases (10.1%) were HER-2 strong positive (+++). 935 cases were p53 positive and 2061 cases were p53 negative. The HER-2 overexpression rate was 32.3% in the p53-positive patients and 18.4% in the p53-negative patients. Expression of HER-2 was positively correlated with expression of p53 (P < 0.01). CONCLUSION: Expression of p53 is the independent index of HER-2 expression, and there is a positive correlation between expression of HER-2 and expression of p53.