同种异体脱细胞真皮基质在膀胱阴道瘘和前尿道狭窄手术中的应用

目的 评价同种异体脱细胞真皮基质（ADMA）在膀胱阴道瘘和前尿道狭窄手术中的应用价值。方法 对4例复杂性膀胱阴道瘘、5例前尿道狭窄患者进行了手术治疗,术中均采用了ADMA作为组织替代物。采用腹膜外经膀胱途径进行膀胱阴道瘘修补,术中将ADMA置入阴道、膀胱之间。前尿道狭窄患者切除狭窄段后以ADMA替代尿道。结果 所有病例均未发生任何手术并发症。4例膀胱阴道瘘患者,术后阴道漏尿停止,随访4～12个月,未见复发。5例前尿道狭窄患者,拔除尿管后3例患者排尿通畅,2例间断进行尿道扩张2个月。术后3个月所有患者均排尿通畅,尿流率达到正常范围,尿道造影未见狭窄征象。结论 在部分下尿路成型手术如膀胱阴道瘘、尿道狭窄中,采用ADMA替代自体组织,手术效果确切,时间短,尤其避免了既往获取自体组织所带来的创伤,是一种安全、有效、微创、经济的新方法。

Usage of acellular dermal matrix allograft in surgical treatment of vesico-vaginal fistula and anterior urethral stricture: report of 9 cases

OBJECTIVE: To assess the value of acellular dermal matrix allograft (ADMA) in surgical treatment of vesico-vaginal fistula (VVF) and anterior urethral stricture. METHODS: Four patients suffering from vesico-vaginal fistula and 5 cases with long anterior urethral stricture received surgical treatment in which ADMA were applied. In the VVF patients the ADMA inserted between the vagina and the bladder during transabdominal extraperitoneal repair. In the patients with anterior urethral stricture the ADMA was sutured to substitute the urethra after resection of the stenosis segment. RESULTS: No intraoperative or postoperative complications occurred. Immediate stoppage of urine leakage from the vagina was seen in the 4 VVF patients, and no recurrence was found during the follow-up of 4 - 12 months. Satisfactory voiding was achieved immediately after removing the catheter in 3 of the 5 cases of urethral stricture, although 2 of the 5 needed urethral sounding for about 2 months. Three months postoperatively all patients were voiding well and their urine flow rates were all normal. Urethrography revealed excellent caliber of the reconstructed urethra. CONCLUSION: In plastic surgery of lower urinary tract such as for VVF and urethra stricture, the ADMA may serve as an ideal replacement material for autologous tissue. Its usage avoids the need to harvest autologous tissue, thus providing a novel, safe, effective, microinvasive and economic method in urologic plastic surgery.